ID W5PDU6_SHEEP Unreviewed; 661 AA.
AC W5PDU6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN Name=LRCH1 {ECO:0000313|Ensembl:ENSOARP00000008610.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008610.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000008610.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008610.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000008610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01013743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01013744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PDU6; -.
DR STRING; 9940.ENSOARP00000008610; -.
DR PaxDb; 9940-ENSOARP00000008610; -.
DR Ensembl; ENSOART00000008735.1; ENSOARP00000008610.1; ENSOARG00000008014.1.
DR eggNOG; KOG0532; Eukaryota.
DR eggNOG; KOG0619; Eukaryota.
DR OMA; ETSPLCE; -.
DR Proteomes; UP000002356; Chromosome 10.
DR Bgee; ENSOARG00000008014; Expressed in spleen and 53 other cell types or tissues.
DR ExpressionAtlas; W5PDU6; baseline and differential.
DR CDD; cd21270; CH_LRCH1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF4; LEUCINE RICH REPEATS AND CALPONIN HOMOLOGY DOMAIN CONTAINING 1; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00033; CH; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 509..625
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 209..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 74635 MW; 224BB33B07687D99 CRC64;
DLSKNRLVEV PMELCHFVSL EILNLYHNCI RVIPEAIINL QMLTYLNLSR NQLSALPACL
CGLPLKVLIA SNNKLGSLPE EIGQLKQLME LDVSCNEITA LPQQIGQLKS LRELNVRRNY
LKVLPQELVD LPLVKFDFSC NKVLVIPICF REMKQLQVLL LENNPLQSPP AQICTKGKVH
IFKYLSIQAC QIKTTDSLYL HTMERPHLHQ HVEDGKKDSD SGVGSDNGDK RLSATEPSDE
DTVSLNVPMS NIMEEEQTKE DSCHRLSPVQ GEFHQEFQPA PSLVSDSDNS GEDRGQFSHG
TDVLHSEFIN YIKEQTEACE ELLRIEEDAH WPSEGTISAS KDQDIDIAMI EQLREAVDLL
QDPDRLSTDI TERSIVNFYP VDPADDLELQ DSALNGQIQL ERSPECEVQN DLTLQSNGSE
YSPSEMRENS PAISPTNTST ALFGLKPRSD PALTLPPISF NKLTQAQTWD NSSYCVPSEG
DSDNVFLRPQ RNLESIDPQF TIRRKMEQMR EEKELVEQLR ESIEMRLKVS LHEDLGAALM
DGVVLCHLVN HIRPRSVASI HVPSPAVPKL SMAKCRRNVE NFLEACRKLG VPEADLCSPY
DILQLDFRHI RKTVDTLLAL GEKPPQPTSA LRSRDLISFC LVHTLFIVLI YITYRWNALP
P
//
