GenomeNet

Database: UniProt
Entry: W5PEW5_SHEEP
LinkDB: W5PEW5_SHEEP
Original site: W5PEW5_SHEEP 
ID   W5PEW5_SHEEP            Unreviewed;      3260 AA.
AC   W5PEW5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   02-DEC-2020, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000008980};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSOARP00000008980};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000008980, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000008980, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000008980,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000008980}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01022632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012043139.1; XM_012187749.2.
DR   STRING; 9940.ENSOARP00000008980; -.
DR   Ensembl; ENSOART00000009110; ENSOARP00000008980; ENSOARG00000008368.
DR   GeneID; 101112149; -.
DR   KEGG; oas:101112149; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   Proteomes; UP000002356; Chromosome 12.
DR   ExpressionAtlas; W5PEW5; baseline.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 3.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 4.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1889..2007
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2095..2234
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2277..2416
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2459..2598
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          3116..3159
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          211..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1243..1265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1526..1546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1663..1689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1714..1748
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3038..3260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..384
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          523..706
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..752
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          839..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..957
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          969..989
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1036..1056
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1089..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1284..1325
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1395..1422
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1547..1617
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1790..1817
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1825..1852
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1886..1913
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1949..2042
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2071..2098
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2106..2242
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2260..2280
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2288..2424
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2470..2613
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2621..2749
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2764..2823
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2835..2862
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2885..2971
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2982..3009
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        475..493
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1530..1544
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1669..1689
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3038..3052
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3064..3078
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3086..3100
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3101..3117
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3145..3159
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3174..3224
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3260 AA;  374082 MW;  24A24328E2591C65 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKERQQRQFQ LETLEAALQK QKQKIENEKT
     EGANLKRENQ SLMEICENLE KTKQKISHEL QVKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ AAQSADVSLN SCLTPQKIFA TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQAIPQS TMNHRDIARH QASSSVFSWQ QEKTPSRLSS NTLKTPVRRD
     FSASHFSGEQ EVTPSRSTLQ IGKTDANSSF CDNSSNSHLL DQLKAQNQEL RSKISELELR
     LQGQEKEMKG QVNKLQELQL QLEKAKVELN EKEKVLNKTR DELVRTTSQY DQASTKCTAL
     EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECTQMKAR
     LTQELQQAKN TYNILQAELD KVTSVKHQVE KKLEEFKQNL SKTEQALQAS QTKENELRRS
     SEEMKRENSL LKSQSEQRAR EVCHLEEELK KAKQCLSQSQ NFAEEMKAKN TSQETMLRDL
     QEKINQQENS LTLEKLKLAL ADLEKQRDCS QDLLKKREHH IEQLNEKLSK TERESEALLS
     ALELKKKEYE ELKEEKTLFS RWKRENEQLL NQMESEKESL QSKVNHLETC LKTQQIKSHE
     YNERVRTLEM ERENLNVEIR NLQNVIDSKT AEAETQKRAY GELQQKAEFS DQKHEKEIEN
     MCLKISHLTG QVEDLEHKLQ LLSSEIMGKD QRYQDLHAEY ESLRDLLKSR DSSAVTVEPH
     QRSRLAFEQQ SALNNSFASI IGEQESVSSE RSGCHVATDQ SPESSSMLQN RVVSLEFSLE
     SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSVHQNVVT
     ETLAALESKE RELQFLNEKL ETEQAEIGEL KKNNHLLQES LKELQFLSET LSLEKKELNS
     IISLNKKDIE GLTQENGTLK EINATLTREK MNLLQKTESF SNCIDERDKS ISELSNQYKQ
     ERLTLLQRCE ETGNAFQDLS EKYKAVQEKN SKLECLLSEC TGVCEDRKNE LGQLKETFAR
     EHQAFVSQLA SAEERNQNLI LELETVQQAL QSEITDIQNS SKREADGLKQ EIMKLKEEQN
     KMQQEVNALL QENEHLMELM RTKHEHQCLE LEPIQDSEKE GEREINTCHV QLPMDLDVKD
     SSLDTYKAQL VQVESEVRNM ELRLQKSEKE ECLQHELQAR ELETEDLQQD TQSQDISSLG
     DSEIDPEEKY ISVLHELSTS QQDNAHLQCS LQTAMNKLNE LEKMCEALQV EKSELISELN
     DSRSECITAT SKMAEEVGKL VKEVETLNDE NGLLQGESVE ETPEGEFGVQ QDEQTSVNLN
     PLDDCNFYEH LTMSNKEVQM HFAELQEKFS SLQSEHKILH EQHCLMSSKM SELQSYVDTL
     KAENSVLSMS LRSAQGDLVK EVTPAPGEEH SLSLSFSCVT DSPGNASLGE SSFYKDLLEH
     TTETSLLHNL EGTVSANQSS VEEVSCSSLE EENLTEKETP SGPLRSTREL ETLCQTYLQS
     LKQLEEEIES QGLTKNKEIE ELKELLSSSR EELDYLRKQY LSENEQWQQK LTDVTAEMES
     KLAAEKRHTE HLTLELEVAR LQLQGLDLSS RSLLGTDIED AIPGGNDSCD IRESEEYTSE
     PKERTPKHEI HQVCEKDVQQ DLSLEMEKIT KTGAARLTEE WSREQSSEAS PEAPVGDPAQ
     GCSECTSELY LPGPNASVPR DVLENQVTIQ SLELKVKETS NENLRLLHGI EERDQKVDNL
     LNEIKELDSK FHLLEVQLTT KIEACVALEK IVEELKKEKL DLNEKLASFS CHNQREESSG
     GLTPSLEMVT SKLPHEDIED DVAKVTDNWR EKCLQVENEL QRVQSEKDSM EHHTLSAEAS
     LEAVQTEKLY LEKDNENKQT VITCLEEGLS VVTSERDQLR GELDTLSKEN QELDQMSEKM
     KEKIRELESH QRECLHLQEQ LQSLEKDSQA LSLVRSELEN QIEQLNKEKD SLVWESESLQ
     TKLSESENEK LAITKALETA LMEKGEVAVR LSSTQEEVHQ LRKGIEKLRV RIEADEKKQL
     HVSEKLKASE RRNDSLQDKV ETLERELQMA EENQELVILD AENCKAEVET LKTQIELTTE
     RLKDLESDLV TIRTEKENLV KQLQEKQGQA SELDTLLSSL KNLLEEKERE KIQMKEESKA
     AVEMLQTQLR ELSEEVAALC DDQETWKVKE QSLDSPAQEV QQLRNNIEKL KLHLDIDKKQ
     QLHILEKLKE SEHQADLLKD TVENLERELK LSGENQEHVT LEAEKSKAEV ETLKATAKEM
     DQNLRGLQLD LVNIRSEKED LTKELLKEQS RVSELQTLNS SFENLLREKE QEKVQMKEES
     KAAVEMLQTQ LKELSEEVAT LYVDQETWKV EEQSLDSPIE EVQQLRNNLG KLKVCLDADK
     KQQLCILEKL KESQHQADFL KDTVENLERE LELSGKNQEH VTLEAEKSKA EVETLKTTME
     EMDQNLRGLQ LDLVNIRSEK EDLSKELQKE QSRVSELETL NSSFENMLRE KEQEKVQMQE
     ESKAAVEMLQ KELEELNEKM AALGNDQETW KVKEQSLSSQ VDSLEHEKAQ LLQGLDDAKS
     NYMILQSSVN DLIQEVEDGK QKLEKKDEEI SILESQTRDQ EQLVSKLSQM EGEQQLWKKQ
     KADLENLMVE LEQKIQVLQS KNDALQDTLE ALQNSYRNLE KELELTNLEK TSFVEKVNTM
     TVKETELQKE MHAMIQKTAE LKEEFSGEKN RLTEELNLML EEVKSSKGQL NELMLENSEL
     KKSLDCVHKD HMEEQGKMRG EIAEYQLRLQ EAENKHQALL LDTNKQHEME IQTYREKLTS
     KEECLSSQKV EIDLLKSSKE ELNNSLKATT EILEELKKTK MENLKHADKL KKENDRAQSK
     IKLLMKSCKQ LEEEKVMLQK ELSHLEAAQE KQRADTVVDA NVDELITEMK ELKESLEEKT
     KEADEYLDKY CSLLISHEKL EKAKEMLETQ VARLSSQQSK LNLRSSPLVN SVAPGPSPVP
     SATEKKLPSG QNKSSGKRQR SSGIREDGGE TTPSTPETFS KKSRKAIKSG THPPEDAEDA
     EFEPEGLPEV VKKGFADIPT GKTSPYILRR TTMATRTSPR LAAQKLAASP LSLDKENLTE
     TSKPTAGGSR SQKVKVSQQS PVDSGTTFRD PTARSLSISN LPERSPAGSP REGLRAKRGH
     HAPSPEASLQ SKGSENCRVQ
//
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