ID W5PF33_SHEEP Unreviewed; 193 AA.
AC W5PF33;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=MD-2-related lipid-recognition domain-containing protein {ECO:0000259|SMART:SM00737};
GN Name=GM2A {ECO:0000313|Ensembl:ENSOARP00000009048.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009048.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009048.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009048.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01093529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01093532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004009037.1; XM_004008988.3.
DR AlphaFoldDB; W5PF33; -.
DR SMR; W5PF33; -.
DR STRING; 9940.ENSOARP00000009048; -.
DR PaxDb; 9940-ENSOARP00000009048; -.
DR Ensembl; ENSOART00000009180.1; ENSOARP00000009048.1; ENSOARG00000008438.1.
DR GeneID; 101105496; -.
DR KEGG; oas:101105496; -.
DR CTD; 2760; -.
DR eggNOG; ENOG502S05S; Eukaryota.
DR HOGENOM; CLU_108261_0_0_1; -.
DR OMA; WIKVPCV; -.
DR OrthoDB; 23272at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000008438; Expressed in ileocolic lymph node and 52 other cell types or tissues.
DR GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR GO; GO:0006689; P:ganglioside catabolic process; IEA:InterPro.
DR Gene3D; 2.70.220.10; Ganglioside GM2 activator; 1.
DR InterPro; IPR028996; GM2-AP.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR003172; ML_dom.
DR PANTHER; PTHR17357:SF0; GANGLIOSIDE GM2 ACTIVATOR; 1.
DR PANTHER; PTHR17357; GM2 GANGLIOSIDE ACTIVATOR PROTEIN; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF63707; Ganglioside M2 (gm2) activator; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..193
FT /note="MD-2-related lipid-recognition domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004870877"
FT DOMAIN 36..188
FT /note="MD-2-related lipid-recognition"
FT /evidence="ECO:0000259|SMART:SM00737"
SQ SEQUENCE 193 AA; 20974 MW; B7D4C5D0A2022D39 CRC64;
MSPLLQAPFL ISVGLLLAGP ALPARILQNR LGSFSWDNCD AGKDPAVINS LTLEPDPIAI
PGNLTITAEA KTSAVLSDPL KVELTVEKHI AGFWVKIPCV DNIGSCTYDN FCNILEMLIP
IEEPCPEPLH TYGLPCHCPF KEGAYSLPKS DFMLPDLELP SWLSTGNYRL QTILSNNEKR
LACVNISASL KGK
//
