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Database: UniProt
Entry: W5PFM3_SHEEP
LinkDB: W5PFM3_SHEEP
Original site: W5PFM3_SHEEP 
ID   W5PFM3_SHEEP            Unreviewed;      2072 AA.
AC   W5PFM3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-APR-2018, entry version 33.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSOARP00000009238};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009238, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000009238, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009238};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000009238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AMGL01091171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01091180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000009374; ENSOARP00000009238; ENSOARG00000008583.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; EKDCRGK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000002356; Chromosome 5.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IEA:Ensembl.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; IEA:Ensembl.
DR   GO; GO:0021679; P:cerebellar molecular layer development; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0021590; P:cerebellum maturation; IEA:Ensembl.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR   GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0051899; P:membrane depolarization; IEA:Ensembl.
DR   GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IEA:Ensembl.
DR   GO; GO:0032353; P:negative regulation of hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0043113; P:receptor clustering; IEA:Ensembl.
DR   GO; GO:0014056; P:regulation of acetylcholine secretion, neurotransmission; IEA:Ensembl.
DR   GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0031335; P:regulation of sulfur amino acid metabolic process; IEA:Ensembl.
DR   GO; GO:0060024; P:rhythmic synaptic transmission; IEA:Ensembl.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR   GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0021750; P:vestibular nucleus development; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     42     62       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     74     94       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    207    228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    410       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    593    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1027   1046       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1099   1116       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1161   1183       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1273   1298       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1354   1372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1384   1407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1475   1493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1571   1595       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1732   1766       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      270    290       {ECO:0000256|SAM:Coils}.
FT   COILED      613    649       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2072 AA;  235598 MW;  9B3C8F441F2E6B54 CRC64;
     TPFEYMILAT IIANCIVLAL EQHLPDDDKT PMSERLDDTE PYFIGIFCFE AGIKIIALGF
     AFHKGSYLRN GWNVMDFVVV LTGILATVGT EFDLRTLRAV RVLRPLKLVS GIPSLQVVLK
     SIMKAMIPLL QIGLLLFFAI LIFAIIGLEF YMGKFHTTCF EEGTDDIQGE SPAPCGTEEP
     ARTCPNGTKC QPYWEGPNNG ITQFDNILFA VLTVFQCITM EGWTDLLYNS NDASGNTWNW
     LYFIPLIIIG SFFMLNLVLG VLSGEFAKER ERVENRRAFL KLRRQQQIER ELNGYMEWIS
     KAEEVILAED ETDGEQRHPF DGALRRATIK KSKTDLLNPE EAEDQLADIA SVGSPFARAS
     IKSAKLENST FFHKKERRMR FYIRRMVKTQ AFYWTVLSLV ALNTLCVAIV HYNQPEWLSD
     FLYYAEFIFL GLFMSEMFIK MYGLGTRPYF HSSFNCFDCG VIIGSIFEVI WAVIKPGTSF
     GISVLRALRL LRIFKVTKYW ASLRNLVVSL LNSMKSIISL LFLLFLFIVV FALLGMQLFG
     GQFNFDEGTP PTNFDTFPAA IMTVFQILTG EDWNEVMYDG IKSQGGVQGG MVFSIYFIVL
     TLFGNYTLLN VFLAIAVDNL ANAQELTKDE QEEEEAANQK LALQKAKEVA EVSPLSAANM
     SIAVKEQQKN QKPAKSVWEQ RTSEMRKQNL LASREALYNE MDPDERWKAS YARHLRPDMK
     THLDRPLVGD PQENRNNNTN KSRAAEQPGF WEGEAERGKA GDPHRRHAHR QAGSRESRSG
     APRTGADGEP RRPRDGGGGE RRRRHRHGPP PAYDADMHRE DKERRHRRRK ENQGSGVPVS
     GPNLSTTRPI QQDLGRQDPP LAEDIDNMKN NKLATAESAS PHDSLSHAGL PQSPAKMGNS
     TDPGPTPAPT NNPGNPSNPG PPKTPENSLI VTNPSSTQAN SAKTARKPDH TTVDIPPACP
     PPLNHTIIQV NKNANPDPLP KKEEEKKEEE EDDPGEDGPK PMPPYSSMFI LSTTNPLRRL
     CHYILNLRYF EMCILMVIAM SSIALAAEDP VQPNAPRNNV LRYFDYVFTG VFTFEMVIKM
     IDLGLVLHQG AYFRDLWNIL DFIVVSGALV AFAFTGNSKG KDINTIKSLR VLRVLRPLKT
     IKRLPKLKAV FDCVVNSLKN VFNILIVYML FMFIFAVVAV QLFKGKFFHC TDESKEFEKD
     CRGKYLLYEK NEVKARDREW KKYEFHYDNV LWALLTLFTV STGEGWPQVL KHSVDATFEN
     QGPSPGYRME MSIFYVVYFV VFPFFFVNIF VALIIITFQE QGDKMMEEYS LEKNERACID
     FAISAKPLTR HMPQNKQSFQ YRMWQFVVSP PFEYTIMAMI ALNTIVLMMK FYGASVAYEN
     ALRVFNIVFT SLFSLECVLK VMAFGILNYF RDAWNIFDFV TVLGSITDIL VTEFGNNFIN
     LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY AIIGMQVFGN
     IGIDVEDEDS DEDEFQITEH NNFRTFFQAL MLLFRSATGE AWHNIMLSCL SGKPCDKNSG
     ILTHECGNEF AYFYFVSFIF LCSFLMLNLF VAVIMDNFEY LTRDSSILGP HHLDEYVRVW
     AEYDPAACGR IHYKDMYSLL RVISPPLGLG KKCPHRVACK RLLRMDLPVA DDNTVHFNST
     LMALIRTALD IKIAKGGADK QQMDAELRKE MMAIWPNLSQ KTLDLLVTPH KSTDLTVGKI
     YAAMMIMEYY RQSKAKKLQA MREEQNRTPL MFQRMEPPSP TQEGGPGQNA LPSTQLDPGG
     GLMAHESGMK ESPSWVTQRA QEMFQKTGTW SPERGPPTDM PNSQPNSQSV EMREMGRDGY
     SDSEHYFPVE GQARAASMPR LPAENQRRRG RPRGNDLSTI SDTSPMKRSA SALGPKARRL
     DDYSLERVPP EENQRHHQRR RDRGHRTSER SLGRYTDVDT GLGTDLSMTT QSGDLPSKRD
     QERGRPKDRK HRQERYAQER PEHGRPRARD QRWSRSPSEG REHMAHRQGS SSVSGSPAPS
     TSGTSTPRRG RRQLPQTPST PRPRVSYSPV IR
//
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