ID W5PG73_SHEEP Unreviewed; 1086 AA.
AC W5PG73;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Calcium-activated potassium channel BK alpha subunit domain-containing protein {ECO:0000259|Pfam:PF03493};
GN Name=KCNT2 {ECO:0000313|Ensembl:ENSOARP00000009438.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009438.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009438.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009438.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009438.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01020103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01020112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PG73; -.
DR SMR; W5PG73; -.
DR STRING; 9940.ENSOARP00000009438; -.
DR PaxDb; 9940-ENSOARP00000009438; -.
DR Ensembl; ENSOART00000009575.1; ENSOARP00000009438.1; ENSOARG00000008788.1.
DR eggNOG; KOG3193; Eukaryota.
DR HOGENOM; CLU_003370_0_0_1; -.
DR OMA; SADASHY; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000008788; Expressed in hippocampal formation and 29 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF9; POTASSIUM CHANNEL SUBFAMILY T MEMBER 2; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 407..501
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 935..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1086 AA; 125517 MW; 17AB2D98C92E1BE5 CRC64;
RVQVEFYMNE NTFKERLKLF FIKNQRSSLR IRLFNFSLKL LSCLLYIIRV LLENPSQFNL
MPGKWMSHIF WVNRSLPLWG LQVLVALISL FETILLGYLS YKKGNIWEQI LRIPFILEII
NAVPFIISIF WPSLRNLFVP VFLNCWLAKH ALENMINDLH RAIQRTQSAM FNQVLILIST
LLCLIFTCIC GIQHLERLTF HFSFFEMLSF TYREFWLSMS GQVINRMWPT QIKILIIPLI
TDVENVLQFE QLAYLWMERQ KSGGNYSRHR AQTEKHVVLC VSSLKIDLLM DFLNEFYAHP
RLQDYYVVIL CPTEMDVQVR RILQIPMWSQ RVIYLQGSAL KDQDLLRAKM DDAEACFILS
SRCEVDRTSS DHQTILRAWA VKDFAPNCPL YVQILKPENK FHIKFADHVV CEEEFKYAML
ALNCICPATS TLITLLVHTS RGQEGQQSPE QWQKMYGRCS GNEVYHIVLE ESTFFAEYEG
KSFTYASFHA HKKFGVCLIG IRREDNKNIL LNPGPRYIMN ATDTCFYINI TKEENSAFKN
HDHQKKSNVP RSFYHGPSRL PVHSIIASMG TVAIDLQDTS CRSASGPTLS LPTEGSKEVR
RPSIAPVLEV ADTSSIQTCD LLSDQSEDET TPDEEMSSNL EYAKGYPPYS PYIGSSPTFC
HLLHEKVPFC CLRLDKSCQH NYYEDAKAYG FKNKLIIVAA ETAGNGLYNF IVPLRAYYRP
KKELNPVILL LDNPLDDLLR CGVTFAANMV VVDKESTMSA EEDYMADAKT IVNVQTLFRL
FSSLSIITEL THPANMRFMQ FRAKDCYSLA LSKLEKKERE RGSNLAFIFR LPFAAGRVFS
ISMLDTLLYQ SFVKDYMISI TRLLLGLDTT PGSGFLCSMK ITEDDLWIRT YARLYQKLCS
STGDVPIGIY RTESQKLTTS ESQISISVEE WEDTKDAKEQ AHHRSNHRNS TSSDQSDHPL
LRRKSMQWAR RLSRKGPKHS SRTAEKMTQQ RLNLYRRSER QELAELVKNR MKHLGLSTVG
YDEMNDHQNT LSYILINPSP DTRLELNDVV YLIRPDPLAY LPNSEPSRKN SICNTMVQDS
REETQL
//
