ID W5PGG8_SHEEP Unreviewed; 1186 AA.
AC W5PGG8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type {ECO:0000256|PIRNR:PIRNR000934};
DE EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000934};
GN Name=PTPN14 {ECO:0000313|Ensembl:ENSOARP00000009534.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009534.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009534.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009534.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009534.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|PIRNR:PIRNR000934};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR000934}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649,
CC ECO:0000256|PIRNR:PIRNR000934}.
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DR EMBL; AMGL01022634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01022638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004013933.1; XM_004013884.2.
DR RefSeq; XP_012043140.1; XM_012187750.2.
DR RefSeq; XP_012043142.1; XM_012187752.2.
DR AlphaFoldDB; W5PGG8; -.
DR Ensembl; ENSOART00000009671.1; ENSOARP00000009534.1; ENSOARG00000008871.1.
DR GeneID; 101112408; -.
DR KEGG; oas:101112408; -.
DR CTD; 5784; -.
DR HOGENOM; CLU_006456_1_0_1; -.
DR OrthoDB; 3108587at2759; -.
DR Proteomes; UP000002356; Chromosome 12.
DR Bgee; ENSOARG00000008871; Expressed in longissimus thoracis muscle and 53 other cell types or tissues.
DR ExpressionAtlas; W5PGG8; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13188; FERM_C_PTPN14_PTPN21; 1.
DR CDD; cd17191; FERM_F1_PTPN14; 1.
DR CDD; cd14599; PTPc-N14; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR014392; PTP_non-rcpt_14/21.
DR InterPro; IPR041782; PTPN14/21_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF6; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 14; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PIRSF; PIRSF000934; Tyr-Ptase_nr14; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR000934};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR000934}; Hydrolase {ECO:0000256|PIRNR:PIRNR000934};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR000934};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 21..306
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 908..1179
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1089..1170
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 309..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1120
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000934-1"
SQ SEQUENCE 1186 AA; 134439 MW; DA0D9BFBDF8095FA CRC64;
MPFGLKLRRT RRYNVLSKNC FVTRIRLLDS SVIECTLSVE STGRECLEAV AQRLELRETH
YFGLWFLSKS QQARWVELEK PLKKHLDKFA NEPLLFFGVM FYVPNVSWLQ QEATRYQYYL
QVKKDVLEGR LRCSLEQVIR LAGLAVQADF GDYNQFDSQD FLREYVLFPM DLALEEAVLE
ELTQKVAQER KAHSGILPAE AELMYINEVE RLDGFGQEIF PVKDNHGNSV HLGIFFMGIF
VRNRIGRQAV IYRWNDMGNI THNKSTILVE LVNKEETALF HTEDIENAKY ISRLFATRHK
FYKQNKICTE QSNSPPPIRR QPTWSRSSLP RQQPYILPPM HVQCGEHYSE THTSQDSIFH
GNEEALYCNS HNSLDLSYLN GTVTNGGSVC SVHSINSLSC SQSFIQASPV SSNLSIPGSD
IMRADYIPSH RHSAIIVPSY RPTPDYETVM RQMKRGVVHT DSQSQSLRNL NIINTHAYNQ
PEDLVYSQPE MRERHPYTIP YGPQGGYANK LVSPSDQLNP TNPTVPSKPG GPSAISHTVS
TPELANMQLQ GAHGYNAAHV LKNYLFRPPP PYPRPRPATS TPDLASHRHK YVSGSSPDLV
TRKVQLSVKT FQEDSSPVVH QSLQEVSEPL TATKHHGAVH KRHSLEAMSS MVRGMQAMTL
KSLNIPTARS RQLREPGPPP AAHEVPQLPQ YHHKKTLSDA TMLIHSSESE EEEEEAPDPV
PQIPVLREKV EYSTQLQAAL ARIPNKPPPE YPGPRKSVSN GALRQDQACL PPAVARARLL
RHGPAKAISV SRADQLAVNG ASLGPSISEP DLTSVKERVK KEPVKERPVS EMFSLEDSII
EREMMIRNLE KQKMAGLEAQ KRPLMLAALN GLSVARGSGR EESRVDATRV PMDERFRTLK
KKLEEGMVFT EYEQIPKKKA NGIFSTAALP ENAERSRIRE VVPYEENRVE LIPTKENNTG
YINASHIKVV VGGAEWHYIA TQGPLPHTCH DFWQMVWEQG ANVIAMVTAE EEGGRTKSHR
YWPKLGSKHS SATYGKFKVT TKFRTDSGCY ATTGLKVKHL LSGQERTVWH LQYTDWPDHG
CPEDVQGFLS YLEEIQSVRR HTNSMLEGTR NLRPPIVVHC SAGVGRTGVV ILSELMIYCL
EHNEKVEVPM MLRLLREQRM FMIQTIAQYK FVYQVLIQFL QNSRLI
//
