ID W5PHL7_SHEEP Unreviewed; 1160 AA.
AC W5PHL7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=ITGAD {ECO:0000313|Ensembl:ENSOARP00000009934.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009934.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009934.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009934.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009934.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AMGL01069103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01069104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PHL7; -.
DR SMR; W5PHL7; -.
DR STRING; 9940.ENSOARP00000009934; -.
DR PaxDb; 9940-ENSOARP00000009934; -.
DR Ensembl; ENSOART00000010077.1; ENSOARP00000009934.1; ENSOARG00000009250.1.
DR eggNOG; KOG3637; Eukaryota.
DR HOGENOM; CLU_004111_3_0_1; -.
DR OMA; EHRYHVN; -.
DR Proteomes; UP000002356; Chromosome 24.
DR Bgee; ENSOARG00000009250; Expressed in spleen and 45 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF132; INTEGRIN ALPHA-D; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1160
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001426617"
FT TRANSMEM 1101..1121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..81
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 155..333
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 344..395
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 448..508
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 568..628
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REGION 1141..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 126869 MW; 520E83DB712F8FAC CRC64;
MSCLGMAFAV VLFLTGLASY HGFNLDVEEP LVFREDIASF GQSVVQFDRS RLVVGAPLEV
VTVNKTGRLY DCMPATRRCQ PISLNTPSEA VDMSLGLSLA ASTHLSQLLA CGPTVHKACG
DNMYIKGTCL LLGSHLQVIR TIPTALPECP NQEMDIAFLI DGSGSIDQTD FKRMKNFVRA
VMDLFKRTNT QFSLMQYSNL MKTHFTFNQF RTIRSSRSLV DPIAQLNGLT FTATGILRVV
RELFHSKNGA RKSARKIIIV ITDGEKFKDP LKYTDVIPEA EKANIIRYAI GVGDAFQAPA
ARQELNIIGS MPSEDHVFKV DNFAALSSIL KRLQEKIFAV EGTQSGTSSS FQHEMSQEGF
SSILTMDGPV LGAVGSFSWS GGAFLYPQNK NPTFINMSQE HVDMRDSYLG YSTELALWKG
VQSLILGAPR HQHTGKVVLF TQVSRQWRPK AEVTGTQIGS YFGASLCSVD VNGDSSSDLV
LIGAPHFYEQ TQGGQVSVCP FPQGRTKWKC DAVLRGELGH PWGRFGAALT ALGDVNGDRL
GGGGGGGPGG GGLFHGTSEL GISPSHSQRI AGSQLSLELQ YFGHSLSGGQ DLTQDGLVDL
AVGARGHALL LRTLPVLKVN VTMKFTPPEV TKAVYQCWDE LTTTVEAGQA TVCLTIHKSS
QDHLGDVQSS VTYDLALDPG RLISRAVFDE TKNWTLTRRK TLGLGEHCDS MKLLLPDCVE
DIVNPIILRL NFSLVGEPIA SSQNLHPVLA VGSQDLFTAS LPFEKNCGQD HLCEGDLSVS
LSFSGLETLV VGSSLELNVT VVVSNEGEDS YGTVISFHYP AGLSYRRTLA IQQPGQRPLR
LACEALPTGN EGLRSSSCSI NHPIFREGIM GIFIVTFDVS YKATLGDKFH LRANISSENN
KPTSNKTTSQ LELPVKYAVY TVISSSGESR DVRNCRASDQ KSRKEAEHRY RVNNLSQREL
AISVHFWVPV LLNGVVVWDV VLVAPLQSLP CVSEREPPQQ PDFQTQMPSS LVLDCSIADC
LRFRCDIPSF GVQEELDFIL KGNLSFGWAS QLLQKKTLVV SMAEVTFNRS VYTQISGQEA
FLRAQVEMVL EEYEVYSPMP LLVSSSMGGL LLLAFITALL YKCGFFKRQY KEMMDNKPED
TAAFNGEDIH SEAPGPLLSE
//
