ID W5PHR9_SHEEP Unreviewed; 434 AA.
AC W5PHR9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=GFAP {ECO:0000313|Ensembl:ENSOARP00000009986.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009986.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009986.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009986.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009986.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01018768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PHR9; -.
DR SMR; W5PHR9; -.
DR STRING; 9940.ENSOARP00000009986; -.
DR PaxDb; 9940-ENSOARP00000009986; -.
DR Ensembl; ENSOART00000010130.1; ENSOARP00000009986.1; ENSOARG00000009311.1.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR HOGENOM; CLU_012560_7_4_1; -.
DR OMA; IMAHQVH; -.
DR Proteomes; UP000002356; Chromosome 11.
DR Bgee; ENSOARG00000009311; Expressed in cerebellum and 30 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..434
FT /note="Glial fibrillary acidic protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869132"
FT DOMAIN 71..379
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 75..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 277..350
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 434 AA; 50032 MW; 6D217062E93274B9 CRC64;
LESREQVYSS SQHLSGTGRR MLEGLGWLPL LCLLLGTRLS LAGMPPPLPA RVDFSLAGAL
NSGFKETRAS ERAEMMELND RFASYIEKVR FLEQQNKALA AELNQLRAKE PTKLADVYQA
ELRELRLRLD QLTANSARLE VERDNLAQDL GTLRQKLQDE TNQRLEAENN LAAYRQEADE
ATLARLDLER KIESLEEEIR FLRKIHEEEV RELQEQLAQQ QVHVEMDVAK PDLTAALREI
RTQYEAVASS NMQEAEEWYR SKAADRNDAA ARNAELLRQA KHEANDYRRQ LQALTCDLES
LRGTNESLER QMREQEERHA REAASYQEAL ARLEEEGQSL KDEMARHLQE YQDLLNVKLA
LDIEIATYRK LLEGEENRIT IPVQTFSNLQ IRETSLDTKS VSEGHLKRNI VVKTVEMRDG
EVIKESKQEH KDVM
//
