ID W5PHS5_SHEEP Unreviewed; 719 AA.
AC W5PHS5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Ral guanine nucleotide dissociation stimulator like 2 {ECO:0008006|Google:ProtNLM};
GN Name=RGL2 {ECO:0000313|Ensembl:ENSOARP00000009992.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000009992.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000009992.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000009992.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000009992.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01058198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PHS5; -.
DR SMR; W5PHS5; -.
DR STRING; 9940.ENSOARP00000009992; -.
DR PaxDb; 9940-ENSOARP00000009992; -.
DR Ensembl; ENSOART00000010136.1; ENSOARP00000009992.1; ENSOARG00000009312.1.
DR eggNOG; KOG3629; Eukaryota.
DR HOGENOM; CLU_010252_0_2_1; -.
DR OMA; IQQWLRG; -.
DR Proteomes; UP000002356; Chromosome 20.
DR Bgee; ENSOARG00000009312; Expressed in mammary gland and 51 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17211; RA_RGL2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF363; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 37..161
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 192..462
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 591..678
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 490..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 77486 MW; 8CFCC061E93D03DA CRC64;
QAPVSVWEEE EDGATFTVTS RQYQPLDPLA PRPPLRSSRK LRAGTLEALV RHLLDTRTSG
ADVTFTAAFL ATHRAFTSTP ALLGLMVDRL EALESHPADE LERTKGVAIS VLSTWLASHP
EDFGSEVKGQ LDRLESFFLR TGYAAGEGIG GGSADLIRNL RSRVDPQTPE LPKPLALPGD
PPADPTDVLV YLADHLAEQL TLLDAELFLN LVPSQCLGGL WGHRDRPGHS HLCPSVRATV
TQFNKVAGAV VSSVLGATST GEGLGEVTVR PLRPPQRARL LEKWIRVAEE CRLLRNFSSV
YAVVSALQSS PIHRLRAAWG EATRDSLRVF SSLCQIFSEE DNYSQSRELL LQEVKLQPSL
EPNSKKSPRS ASRGGGVVPY LGTFLKDLVM LDAASKDELE NGYINFDKRR KEFAVLSELR
RLQNECRGYD LRPDPDIQRW LQGLRPLTEA QSHRVSCEVD DAGSSDPPAP RVLRPTLVIS
QWTEVLGSVG GPTPLVSWDR PSVGAEEVPG TPAPLLTRLA QHVKWPSVSS LDSALESTPA
LQSPADPSHL SPPASPHRRS ASCGSPLSGG AEGASRGPGC GGGAPGPGAS DCRIIRVQME
LGEDGSVYKS ILVTSQDKAP SVISRVLKKN NRDSAVASEY ELVQLLPGER ELTIPASANV
FYAMDGASHD FLLRRRRRPQ TTVGLASGPS ASGTPPSEGG GGSFPRIKAT GRKIARALF
//
