ID   W5PIN1_SHEEP            Unreviewed;       167 AA.
AC   W5PIN1; A0A6P3THG6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Ubiquitin-fold modifier-conjugating enzyme 1 {ECO:0000256|ARBA:ARBA00013306, ECO:0000256|PIRNR:PIRNR008716};
GN   Name=UFC1 {ECO:0000313|Ensembl:ENSOARP00000010300.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010300.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000010300.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010300.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000010300.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: E1-like enzyme which specifically catalyzes the second step
CC       in ufmylation. Ufmylation is involved in reticulophagy (also called ER-
CC       phagy) induced in response to endoplasmic reticulum stress.
CC       {ECO:0000256|PIRNR:PIRNR008716}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UFC1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008451,
CC       ECO:0000256|PIRNR:PIRNR008716}.
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DR   EMBL; AMGL01005213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004002734.1; XM_004002685.3.
DR   RefSeq; XP_012040218.1; XM_012184828.2.
DR   AlphaFoldDB; W5PIN1; -.
DR   SMR; W5PIN1; -.
DR   STRING; 9940.ENSOARP00000010300; -.
DR   PaxDb; 9940-ENSOARP00000010300; -.
DR   Ensembl; ENSOART00000010453.1; ENSOARP00000010300.1; ENSOARG00000009605.1.
DR   GeneID; 101102771; -.
DR   KEGG; oas:101102771; -.
DR   CTD; 51506; -.
DR   eggNOG; KOG3357; Eukaryota.
DR   HOGENOM; CLU_101170_0_0_1; -.
DR   OMA; PLWAKNV; -.
DR   OrthoDB; 67279at2759; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   Bgee; ENSOARG00000009605; Expressed in pituitary gland and 54 other cell types or tissues.
DR   GO; GO:0061657; F:UFM1 conjugating enzyme activity; IEA:InterPro.
DR   GO; GO:0071569; P:protein ufmylation; IEA:InterPro.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR014806; Ufc1.
DR   PANTHER; PTHR12921; UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1; 1.
DR   PANTHER; PTHR12921:SF0; UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1; 1.
DR   Pfam; PF08694; UFC1; 1.
DR   PIRSF; PIRSF008716; DUF1782; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR008716}.
FT   ACT_SITE        116
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR008716-1"
SQ   SEQUENCE   167 AA;  19401 MW;  17D429086CC52E05 CRC64;
     MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK
     EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PATAPEIAVP ELDGKTAKMY RGGKICLTDH
     FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCSQ
//