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Database: UniProt
Entry: W5PIU5_SHEEP
LinkDB: W5PIU5_SHEEP
Original site: W5PIU5_SHEEP 
ID   W5PIU5_SHEEP            Unreviewed;       450 AA.
AC   W5PIU5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 31.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL1 {ECO:0000313|Ensembl:ENSOARP00000010365};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010365, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000010365, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010365};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000010365}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AMGL01045616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004018490.1; XM_004018441.3.
DR   STRING; 9940.ENSOARP00000010365; -.
DR   Ensembl; ENSOART00000010520; ENSOARP00000010365; ENSOARG00000009664.
DR   GeneID; 101121207; -.
DR   KEGG; oas:101121207; -.
DR   CTD; 3373; -.
DR   GeneTree; ENSGT00950000182708; -.
DR   KO; K01197; -.
DR   OMA; VQIFYDM; -.
DR   OrthoDB; 1096692at2759; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0036117; C:hyaluranon cable; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0050501; F:hyaluronan synthase activity; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR   GO; GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; IEA:Ensembl.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:1900106; P:positive regulation of hyaluranon cable assembly; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   GO; GO:0000302; P:response to reactive oxygen species; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     36       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        37    450       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004869433.
FT   ACT_SITE    146    146       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    365    365       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     58    348       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    222    236       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    373    384       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    378    433       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    435    444       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   450 AA;  50384 MW;  7D04EC1A7DFF466B CRC64;
     MRPFSPEVSL HLPWAMAAHL LPVCTLFLNL LSMTQGSRDP VVPNQPFTTI WNANTEWCMK
     KHGVDVDISI FDVVTNPGQT FRGPNMTIFY SSQLGTYPYY TSAGEPVFGG LPQNASLNVH
     LAHTFQDILA AMPEPHFSGL AVIDWEAWRP RWAFNWDTKD IYRQRSQALV QKQHPDWSAS
     QVEAAAQEQF EGAAEEWMAG TLKLGQALRP QGLWGFYNFP ECYNYDFKSP NYTGQCPPNI
     RAQNDQLRWL WAQSCALYPS IYLPAALEGT KKAQMYVQHR VAEAFRVVAG AGDPKLPVLP
     YMQLFYDMTN HFLSPEELEH SLGESAAQGA AGVVLWVSWA NTSTKESCQA IKEYVETTLG
     PSILNVTSGA RLCSQVLCSG HGRCARRPSY PKARLILSST SFSIKPTPGG GPLTLQGALS
     LGDRLRMAVE FECRCYRGWR GTRCEQWGLW
//
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