ID W5PIV5_SHEEP Unreviewed; 735 AA.
AC W5PIV5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=F5/8 type C domain-containing protein {ECO:0000259|PROSITE:PS50022};
GN Name=CPXM2 {ECO:0000313|Ensembl:ENSOARP00000010375.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010375.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010375.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010375.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010375.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; AMGL01064475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01064476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01064477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01064478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01064479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01064480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PIV5; -.
DR SMR; W5PIV5; -.
DR STRING; 9940.ENSOARP00000010375; -.
DR PaxDb; 9940-ENSOARP00000010375; -.
DR Ensembl; ENSOART00000010530.1; ENSOARP00000010375.1; ENSOARG00000009670.1.
DR eggNOG; KOG2649; Eukaryota.
DR HOGENOM; CLU_006722_4_0_1; -.
DR OMA; TSTKNCM; -.
DR Proteomes; UP000002356; Chromosome 22.
DR Bgee; ENSOARG00000009670; Expressed in aortic valve and 53 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd03869; M14_CPX_like; 1.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF45; INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 113..272
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 83013 MW; 081B4FA6B28F0011 CRC64;
GGEGGAVEDP ADDVQETWSL EPSYARLEPE PEPFSPPLPA GPGAGERGPR PPQPRPPKKA
TAKPKKAPKR EKLAPQTPRP GKNNSRKGVR TKSSEKAASD DQGTPLARDA VREGCPPLGL
ETLKITDFQL HASTSKRYGL GAHRGRLNIQ AGINENDFYD GAWCAGRNDL HQWIEVDARR
LTKFTGVITQ GRNSLWLSDW VTSYKVMVSN DSHTWVTVKN GSGDMIFEGN SEKEIPVLNE
LPVPMVARYI RINPQSWFDN GSICLRMEIL GCPLPDPNNY YHRRNEMTTT DDLDFKHHNY
KAMRQLMKVV NEMCPNITRI YNIGKSHQGL KLYAVEISDH PGEHEVGEPE FHYIAGAHGN
EVLGRELMLL LMQFLCQEYL AGNLRIVRLV EETRIHILPS LNPDGYEKAY EGGSELGGWS
LGRWTHDGID INNNFPDLNT LLWEAEDRQN VPRKVPNHYI AIPEWFLSEN ATVAVETRAV
IAWMEKIPFV LGGNLQGGEL VVAYPYDMVR SLWKTQEHTP TPDDHVFRWL AYSYASTHRL
MTDARRRVCH TEDFQKEDGT VNGASWHTVA GSLNDFSYLH TNCFELSIYV GCDKYPHESE
LPEEWENNRE SLIVFMEQVH RGIKGLVRDL HGKGIPNAVI SVEGVNHDIR TASDGDYWRL
LNPGEYVVTA KAEGFTSSTK NCMVGYDMGA TQCDFTLSKT NLARIREIME KFGKQPVSLP
ARRLKLRGRK RRQRG
//
