ID W5PJ02_SHEEP Unreviewed; 710 AA.
AC W5PJ02;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Transglutaminase-like domain-containing protein {ECO:0000259|SMART:SM00460};
GN Name=TGM7 {ECO:0000313|Ensembl:ENSOARP00000010422.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010422.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010422.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010422.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AMGL01042841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PJ02; -.
DR SMR; W5PJ02; -.
DR STRING; 9940.ENSOARP00000010422; -.
DR PaxDb; 9940-ENSOARP00000010422; -.
DR Ensembl; ENSOART00000010577.1; ENSOARP00000010422.1; ENSOARG00000009715.1.
DR eggNOG; ENOG502QTRA; Eukaryota.
DR HOGENOM; CLU_013435_1_0_1; -.
DR OMA; TDHITFV; -.
DR Proteomes; UP000002356; Chromosome 18.
DR Bgee; ENSOARG00000009715; Expressed in ruminant reticulum and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR013808; Transglutaminase_AS.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR11590:SF41; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE Z; 1.
DR Pfam; PF00927; Transglut_C; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 271..364
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT ACT_SITE 279
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 338
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT ACT_SITE 361
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT BINDING 401
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 403
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 450
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT BINDING 455
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ SEQUENCE 710 AA; 79672 MW; 840A964442ED36CE CRC64;
HPPVAALELR SVDLQSAKNN QEHHTQEMGL QRLIVRRSQS FTIQLHFNRP FHSKNDSITF
VAETGPAPKE LLGTRATFLL TQARQGNGWS ASDFTVHANS LYVSLFTPPS AVIGPYSLKM
EISQGPSHST THPLGTFILL FNPWSAEDDV YLPSETLLQE YIMMDYGFVY KGHERFITPW
PWNYGQFEED IIDICFEILN KSLYFLKNPS KDYSQRNDVV YICRVVSAMI NSNDDSGVLQ
GNWGEDYSRG VSPLEWTGSV AILRQWAARG GQPVKYGQCW VFAAVMCTVM RCLGVPTRVV
SNFRSAHNSD ANLTIDTYYD QHAEMLPTQK RDKIWNFHVW NECWMIRKDL PPGYNGWQVL
DPTPQQTSSG LFRCGPASVK AIREGEIHLP YDTPFVYAEV NADEVVWLLK DGQAQEILAH
NTSSIGKEIS TKMVGSDQRE NITSSYKYPE GSPEERSVFM KASQKTLGVR RTSSPFLDLL
GSGGAVGQPA QLQLHLTRKP EWGQDLLLKL HARRVADRAH PQGPIHLVVD FCAQTLLHNG
GTRKPLWRQK VHLTLDFGED IQWPLSLPYN NYRNKLTDEK LIRVSGIAKV EETGRSMLVL
KDISLEPPHL SIEVSERAEV GKALRVHISL TNTLSVPLSH CTMVLEGSGL VSGQISNDLG
TLVAGHTIKI QVDLYPIKAG PRQLQVLVSS NEIKEIKGYK DIFVAAARAP
//