ID W5PK23_SHEEP Unreviewed; 396 AA.
AC W5PK23;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN Name=KISS1R {ECO:0000313|Ensembl:ENSOARP00000010794.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000010794.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000010794.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000010794.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000010794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMGL01092721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01092722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PK23; -.
DR STRING; 9940.ENSOARP00000010794; -.
DR PaxDb; 9940-ENSOARP00000010794; -.
DR Ensembl; ENSOART00000010952.1; ENSOARP00000010794.1; ENSOARG00000010064.1.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_6_4_1; -.
DR OMA; YPLPTWV; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000010064; Expressed in gastric lymph node and 46 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008103; KiSS_1_rcpt.
DR PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24230:SF78; KISS-1 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01728; KISS1RECEPTR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023040};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..322
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 396 AA; 43084 MW; A470CD1F34A48247 CRC64;
MQPLSASGPN ASWWAPANTT VCPGCGANTS DGAIPAPWPV DAWLVPLFFG ALMLLGLTGN
SLVIFVICRH KQMRTVTNFY IANLAATDLM FLLCCVPFTA LLYPLPDWVL GDFMCKFLNY
IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLGIWVGS AVLSAPVFAL
HRLSSGPRTY CSEAFPSRAL ERAFASCAAL MQARLSCRRR CSPYIACLPD PAPTAARPSP
AAPLSGQLLV ERAGAVRAKV SRLVPAVVLL FAACWGPIQL FLLLQALGPA GAWHPRSYAA
YALKIWAHCM SYCNSALNPL LYAFLGSHFR QAFRRVCPCA PRPLPRAPSS CSCCCRRWAR
PVPGIRAVTL GQARPPEPKI IIVKRPCPLA TFDTNL
//
