ID W5PKQ1_SHEEP Unreviewed; 730 AA.
AC W5PKQ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Vinexin {ECO:0008006|Google:ProtNLM};
GN Name=SORBS3 {ECO:0000313|Ensembl:ENSOARP00000011024.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011024.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000011024.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011024.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000011024.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01048549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01048550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01048551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01048552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01048553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PKQ1; -.
DR SMR; W5PKQ1; -.
DR STRING; 9940.ENSOARP00000011024; -.
DR PaxDb; 9940-ENSOARP00000011024; -.
DR Ensembl; ENSOART00000011184.1; ENSOARP00000011024.1; ENSOARG00000010280.1.
DR eggNOG; KOG4225; Eukaryota.
DR HOGENOM; CLU_026296_0_0_1; -.
DR OMA; VHREPRL; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000010280; Expressed in tricuspid valve and 51 other cell types or tissues.
DR CDD; cd11921; SH3_Vinexin_1; 1.
DR CDD; cd11924; SH3_Vinexin_2; 1.
DR CDD; cd11918; SH3_Vinexin_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR035609; Vinexin_SH3_1.
DR InterPro; IPR035608; Vinexin_SH3_2.
DR InterPro; IPR035607; Vinexin_SH3_3.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14167:SF54; VINEXIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF14604; SH3_9; 2.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 163..229
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 440..499
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 514..575
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 671..730
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..377
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 81317 MW; 4AC9F572567B9EF0 CRC64;
MARIPGVRRS SASPSLENKE ENERDVALNH QDPDRGHAEE QLSSLDPSMQ APPHSLPAGL
SLDDFIPGHL LAHVGSSAQG TRVPVIRNGG SNTLNFQFHD PAPRTVCNGY LPPRRDASRH
PDPAWYQTWP GPGSRPPGNQ KTPASQHSQK WSATWTKDSK RRDKRWVKYE GIGPVDESGM
PIAPRSSVDS PRDWYRRMFK QIHRKMPATL DLQLDWTFEE APKASVDSSC ATSANSRHPG
PQQRPPARPN QKSPLSGRSW DVSEESLRST FSCSPGAPSS LHQTSKQVLR CREKADNIWT
EESWNQFLQE LETGQKPKKP LVDDPVEKPS QPIEVLLERE LAKLSAELDK DLRAIETGQP
PPQPLPPLGP PGGRRNPEPR SPASAWSSSS PNALYPSSSL SPHRMADGGS PFLGRRDFVY
PSSTRDPSDP GGSPARKEEK KRKAARLKFD FQAQSPKELT LKKGDIVYIH KEVDKNWLEG
EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT YQVLEYGEAV AQYNFKGDLE VELSFRKGER
VCLIRKVNEH WYEGRISGTG RQGIFPASYV QVTREPRVRL CDDGPQLPAS PRLPTARLVH
HPSSPLTPRS PADPTDWGGQ TSPRRTGVSF PPQESRPQTQ SLSTPGSALS HPGGSSHPQD
LGTLSSTTSE IHWTPYRAMY QYRPQNEDEL ELREGDRVDV MQQCDDGWFV GVSRRTQKFG
TFPGNYVAPV
//
