ID W5PL30_SHEEP Unreviewed; 2112 AA.
AC W5PL30;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Calx-beta domain-containing protein {ECO:0000259|SMART:SM00237};
GN Name=FREM3 {ECO:0000313|Ensembl:ENSOARP00000011153.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011153.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000011153.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011153.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000011153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01037551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01037552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01037553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01037554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9940.ENSOARP00000011153; -.
DR PaxDb; 9940-ENSOARP00000011153; -.
DR Ensembl; ENSOART00000011313.1; ENSOARP00000011153.1; ENSOARG00000010400.1.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR HOGENOM; CLU_001041_1_0_1; -.
DR OMA; ATKDIFY; -.
DR Proteomes; UP000002356; Chromosome 17.
DR Bgee; ENSOARG00000010400; Expressed in renal medulla and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 3.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF5; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 3; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF03160; Calx-beta; 3.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 3.
DR SUPFAM; SSF141072; CalX-like; 3.
DR PROSITE; PS51854; CSPG; 11.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..2112
FT /note="Calx-beta domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004871031"
FT REPEAT 278..376
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 401..491
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 512..645
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 670..776
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 797..888
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1036..1138
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1159..1252
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1273..1372
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1392..1484
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1504..1593
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1632..1725
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1732..1831
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1844..1955
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1970..2079
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 2112 AA; 234819 MW; 61A439AA0898D0B2 CRC64;
MAGISPRPAG TPRQLAAALA YLLLSCPALQ GQTPSPEAEP PRAPYLPTWG ALGRSSPDGP
NILLANPGLR VPVGRSLWLD PLRDLVIRVQ PGDRCEVTVL DALPPRHGAL SPRRFPCAFG
PRQVRYTHWG ARSPGRARVR LQLRYDAGTS TLALPFVLAV DVVFHRLKLV TRNRPLAVEE
LRGWSHAIDR RVLAFASPEP GTAATRRCRL TLVPPEGGPL PKYGRLVDAA GAPLPRAKAI
DCEAFIRAGV RYQHTSPTPS PNRDYVPMVE GLLHTAPRPS LAAPMMLEVH QFLLTALTPD
ALAAEDKESN ADDLVFNILN APITTPRHQG YVVSTDDPLG LPVSFFSQRE LQELKIAYQP
PTEKLDAEHL FQLEMEVVDT DGATSDPFAF MVVMKPLNTL APVASYDRGL LVFEGQSRPL
SSANSLQISD SDHLGEVKVS AIRGLRHGQL VVLGAPAGCK HFTPTDLAAG RVVYQHDGSN
TYSDNIVFRM EDGHHQVEFL FPLTIIPVDD EPPMVTANAG LSVTEGQVVQ ISPFVLSAMD
IDSEDSTIHF VLEDQPLEEE EERGGDLAPN SSSSRQHLGE ILLRQSEPPW APEDEGWYYV
GKEGLYEKVV TEWLQQDIVE GRLFYRHLGP LGPQSIMAQI TFHVQDDHDP PNLSKQHFFT
IRVQPVDLQS PELFPGTTLE MTVQQYQLTH FQKKFLRYID RDSDDQHLWY TLLMPPTDTD
GNHQVRAGEI VLTDSPDTPI VHFTQAQVNH HEVAYQPPWK KLGIVPRIVQ FTYQVEDAAS
NSVPGTFTLF LKPVDNQPPQ VTNRGFTVLE GESFSLSSNE LHVSDPDTDI DQIVFILVWG
PQHGHLQYLK KCMVPGEYFT QADVVNGSIS YQNHRNQASS DTFHLEVSDK VHHIPITVQI
SVHPAAADKS PRTSIIGSAL LDVSIDVLEN TATEITMDII HGLKGTGDLM LSFTVKDSPK
LGTILVNGLL TERFTQEDLT SGTVVYVHTG GEVGFQKQHD AFRLALSKDS HQRMMGDSTV
EEVRVQVVVL PVNNVAPRVL VREPYVVHEG GKSALTLQHL SIEDADTPQD EILCTVTGQP
VSGYLENMTP APGSEETRAG YPISAFSIRD VQLRHINYVQ SIHKGVEPQK DQFTFYCSDG
INFSPNVFFP IMILPTNDEQ PELFAREFVV LEGMSIVIDT PLLSGADADL PPNELHFQLT
ALPRHGRIIQ QLATESQPIR SFTLQEIQEA STVVYEHDDS ETTEDSFEVW LSDGKHTTHR
TVPIVVILVD DETPRLTIND GLEVETGHTE LITNRVLKAT DLDSDDKSLS FILRSGPQQG
LLQRLGKPRG EVRNNLTLGM NFTQGEIDRG LICYSHTSQG LHDLIKFDVT DGINTLLDCY
FNITIGSLDR VFFPEVVSKG ITLTEGGRVT LTTDLLNTSD INSFDEQLHF SMTQAPRLGH
LEISDHPGEP ITSFTQRQLA GNKIVYVRTS NDEIKMDSFE FQETGEHNPV FQTFRIFITD
VNNKKPIMTI RKLILQEGER KCITPFELTA EDKDTPDDLL LFTITQVPIH GRIVYNGSRP
VTTFTQRDLN ENWICYWHDG SETTEDSFSL TVTDGTHADF YVFPNTAVET HRPQVMWIHI
RNSLESRFSQ TAFNRDALAL KHLHPGHVGF LITSRSLKTE DWDSSRRLHK YKVTRGPVHG
FIVNTGLGNE STRVFTQADI DEMRIYYILN EGSKATKDIF YFSAEDNGGN KLTNQPFHLS
WAWIALEKQY YIVDEDSTFL EVTLTRRGSL GETSFISVVT KDETAKKDKD FKGKAQKQVQ
FSPGQTTATW KVRILSDYEY EASETFQIIL TNPVGAVLEF PEVATVEIVD PEDESTVYIP
EAEYKIEEDA GELLIPVRRS GDISQELTVI CSTHEGSAIG TISSAELSFS DYISRPNDHT
SILHFDKDEA ESTCRVLIIN DSLYEEAESF SISLSLPKGG HLGAKFPTTK VIILADHDDV
SPEPALHFGD AEYHVDESAG SVEVCVRRTG TDLSQASSVT VRSKRTEPAS AEAGLDYIGV
SQKLNFAPGV RVQMFRVTIL ADLGQPIFEG PERFELLLQM PLGAALGEPN KTTIFINDTV
TDCKQSACPP FG
//
