ID W5PL31_SHEEP Unreviewed; 1165 AA.
AC W5PL31;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Leptin receptor {ECO:0000256|ARBA:ARBA00019169};
DE AltName: Full=OB receptor {ECO:0000256|ARBA:ARBA00031601};
GN Name=LEPR {ECO:0000313|Ensembl:ENSOARP00000011154.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011154.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000011154.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011154.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000011154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AMGL01002102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PL31; -.
DR STRING; 9940.ENSOARP00000011154; -.
DR PaxDb; 9940-ENSOARP00000011154; -.
DR Ensembl; ENSOART00000011314.1; ENSOARP00000011154.1; ENSOARG00000010394.1.
DR eggNOG; ENOG502RK5B; Eukaryota.
DR OMA; FPPHCLF; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000010394; Expressed in placental caruncle and 40 other cell types or tissues.
DR ExpressionAtlas; W5PL31; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR041182; LEP-R_IGD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF151; MYOTACTIN FORM B; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR Pfam; PF18589; ObR_Ig; 2.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 239..333
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 539..634
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 740..833
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 1165 AA; 132213 MW; C3B98401A5FC2488 CRC64;
MICQKFCVAL LHWEFIYVTT AFNLAYPITP WKFKLSCMPS NTTYDFLFPP GISKNTSNLN
GRSEAVVETK LNSSGNYLSN LSSRTTFHCC FWSEEDKNCS VYADDIEGKA FVITVNSLVF
QQTGAHWNIQ CWMKEDLKLF ICYIESLFKN PFKNYDLKVH LLYVLLDLLE ESPLLPEKGS
FHIVQCNCSF NECCECHVPV PTAKLNNTLL MYLKITSGGV IFHSPPMSAQ PINVVKPDPP
LGLHMEITDT GSLKISWSSP TLVPFQLQYQ VKYSENSTKN MKKADEIVTA TSLLVDSVLP
GSSYDVQVRS KRLDGLGIWS DWSALLTFTT QDVIYFPPKI LTAVGSNISF HCIYKNEKKI
VSSKKIVWWL NLAEKIPQSQ YDVVDDHISK VTFPNLNATK PRGKFTYDAV YCCNEQECHH
RYAELYVIDV NINISCETDG YLTKMTCRWS PNAIQSLAGS NLQLRYHRSS LYCSDVPSVH
PVSEPKDCHL QRDGFYECIF QPIFLLSGYT MWIRINHTLG SLDSPPVCVI PDSVVKPLPP
SSVKAEITVK IGLLKISWEK PVFPENNLQF QIRYGLSGKQ VQWKMFEVYD AKLKSASLPV
PDLCAVYTVQ VRCKRLDGLG YWSNWSTPAH TVVVDVKVPI RGPEFWRIIS EDTTKKERNV
TLLWKPLMKN DSLCSVRRYV VKHHTSHNGT WLEDVGNHTK LTFLWTEQAH SVMVLAINSI
GASSANFNLT LSRSISKVNI VQSLSAYPLN STCVILSWML SPSDYNLMYF ILEWKILNED
SEIKWLRIPS SVKKYYVHDH FIPIEKYQFS LYPVFTEGVG KPKIINSFTQ DDEKHQHDAD
LYVIVPIIIS SSILLLGTLS VSHQRMKKLF WEDVPNPKNC SWAQGLNFQK PETFEHLFIK
HTESATFGPL LLEPETISED ISVDTSWKNK DEMVPTTTDA LLLTTPDLGK GSICISDQCS
SAQFSEAEST DITCEDGSRR QPSVKYATLL GSSKSGEAEE EQGLINSSAS KCFLSNHSPP
KESSSKRSWE IETQAFFILS DQHPNIISPH LPFSEGLDEL LKLEGNFPKE NNNERPVYYL
GVTSIKKRES DVFLTNESRV LSPFPAHCLF TDIRILQDSC SHLVENNFNL GTSGQKTFVS
YLPQFQTCST QTQKIMENKM CDLTV
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