GenomeNet

Database: UniProt
Entry: W5PMD8_SHEEP
LinkDB: W5PMD8_SHEEP
Original site: W5PMD8_SHEEP 
ID   W5PMD8_SHEEP            Unreviewed;      1500 AA.
AC   W5PMD8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-OCT-2019, entry version 41.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000011613};
GN   Name=ARHGAP35 {ECO:0000313|Ensembl:ENSOARP00000011613};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000011613, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000011613, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000011613,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000011613}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01029217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01029218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01029219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004015381.1; XM_004015332.3.
DR   Ensembl; ENSOART00000011779; ENSOARP00000011613; ENSOARG00000010829.
DR   GeneID; 101117354; -.
DR   KEGG; oas:101117354; -.
DR   CTD; 2909; -.
DR   GeneTree; ENSGT00950000182819; -.
DR   KO; K05732; -.
DR   OrthoDB; 110157at2759; -.
DR   Proteomes; UP000002356; Chromosome 14.
DR   ExpressionAtlas; W5PMD8; baseline.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN      270    327       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      368    422       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      429    483       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      485    550       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      592    767       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      783    947       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1250   1437       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION     1061   1087       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1125   1147       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1178   1208       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1444   1500       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      413    440       {ECO:0000256|SAM:Coils}.
FT   COILED      485    505       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1125   1140       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1183   1197       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1449   1470       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1471   1487       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1500 AA;  170413 MW;  9DA5D2AFA06B2BE4 CRC64;
     MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST
     SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHVVEQTEFI DDQTFQPHRS TTLQPYIKRA
     AATKLASAEK LMYFCTDQLG LEQDFEQKQM PDGKLLIDGF LLGIDVSRGM NRNFDDQLKF
     VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF
     STLVQLIDKS RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWLSVSRKMQ
     ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA LIPNLDEIDH
     LSCIKAKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE RIPFDLMDTV PAEQLYEAHL
     EKLRNERKRA EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMDIYGKH
     QKQIIDKAKE EFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER
     DALILKHIHF VYHPTKETCP SCPACVDAKI EHLVSSRFIR PSDRNQKNSL SDPNIDRINL
     VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG
     CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLAHLPLTL ILVNKRGDTS GETLHSLIQQ
     GQQIASKLQC VFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADV
     DLRIVMCLMC GDPFSADDIL FPVLQSQTCK SSHCGSNNSV LLELPIGLHK KRIELSILSY
     HSSFSIRKSR LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAVDVLDNDL
     SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LEIFHPFFKD VVDKKNIIEA THMYDNAAEA
     CSTTEEVFNS PRAGSPLCNS NLQDSEEDIE TPSYSVFRED TPLPPLSKDH SKLSMELEGN
     DGLSFIMSNF ESKLNNKVPP PVKPKPPVHF EITKGDLSYL DQGHRDGQRK SVSSSTWLPP
     DGFDPSDYAE PMDAVVKPRN EEENIYSVPH DSTQGKIITI RNINKAQSNG SGNGSDSEMD
     TSSLERGRKV SIVSKPVLYR TRCSRLGRFA SYRTSFSVGS DDELGPIRKK EEDQASQGYK
     GDNAVIPYET DEDPRRRNIL RSLRRNTKKP KPKPRPSIAK AAWESNYFGV PLTTVVTPEK
     PIPVFIERCI EYIEATGLST EGIYRVSGNK SEMESLQRQF DQDHNLDLAE KDFTVNTVAG
     AMKSFFSELP DPLVPYNMQI DLVEAHKIND REQKLHALKE VLKKFPKENH EVFKYVISHL
     NRVSHNNKVN LMTSENLSIC FWPTLMRPDF STMDALTATR TYQTIIELFI QQCPFFFHNR
     PISEPPGATP SSPSALASTV PFLTSTPVTS QPSPPQSPPP TPQSPMQPLL PSQLQAEHTL
//
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