GenomeNet

Database: UniProt
Entry: W5PNP1_SHEEP
LinkDB: W5PNP1_SHEEP
Original site: W5PNP1_SHEEP 
ID   W5PNP1_SHEEP            Unreviewed;       432 AA.
AC   W5PNP1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Milk fat globule EGF and factor V/VIII domain containing {ECO:0000313|Ensembl:ENSOARP00000012067.1};
GN   Name=MFGE8 {ECO:0000313|Ensembl:ENSOARP00000012067.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012067.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000012067.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012067.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000012067.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AMGL01041411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01041412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PNP1; -.
DR   SMR; W5PNP1; -.
DR   STRING; 9940.ENSOARP00000012067; -.
DR   PaxDb; 9940-ENSOARP00000012067; -.
DR   Ensembl; ENSOART00000012243.1; ENSOARP00000012067.1; ENSOARG00000011260.1.
DR   eggNOG; ENOG502QVK3; Eukaryota.
DR   HOGENOM; CLU_030066_0_1_1; -.
DR   OMA; YVKTFKV; -.
DR   Proteomes; UP000002356; Chromosome 18.
DR   Bgee; ENSOARG00000011260; Expressed in vas deferens and 52 other cell types or tissues.
DR   CDD; cd00054; EGF_CA; 2.
DR   CDD; cd00057; FA58C; 2.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR24543:SF317; LACTADHERIN; 1.
DR   PANTHER; PTHR24543; MULTICOPPER OXIDASE-RELATED; 1.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   SMART; SM00181; EGF; 2.
DR   SMART; SM00231; FA58C; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 2.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01285; FA58C_1; 2.
DR   PROSITE; PS01286; FA58C_2; 2.
DR   PROSITE; PS50022; FA58C_3; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..432
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004869336"
FT   DOMAIN          28..65
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          68..111
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          114..270
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DOMAIN          275..432
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   DISULFID        55..64
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        101..110
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   432 AA;  48360 MW;  7B36A4986FBB6911 CRC64;
     MPSPRLLAAL WAALCCLSGH HLFPLTCDLC DSSQCLHGGT CLLNEEKTPP FYCLCPEGFT
     GLLCNETEYG PCFPNPCHND AECQETDSLR GDVFTHYTCK CSLGYVGTHC ENTCTSPLGM
     QTGAIADSQI SASSMHLGFM GLQRWAPELA RLYQTGIVNA WTSSNYDKTP WIQVNLLRKM
     WVTGVVTQGA SRAGSAEYVK TFKVAYSNDG RQFQFIQVAG QLGDKIFVGN RNNSGLKINL
     FDSPLEVQYV RLVPIICRRG CTLRFELLGC ELDGCTEPLG LKHNTIPDKQ ITASSYYKTW
     GLSAFSWFPY YARLDNWGKF NAWTAQTNSA SEWLQIDLGS QKRVTGIITQ GARDFGHIQY
     VAAYRVAYSD DGVTWTEYKD PETSKSKIFP GNMDNNSHKK NIFEVPFQAR FVRIQPVAWH
     NRITLRVELL GC
//
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