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Database: UniProt
Entry: W5PP08_SHEEP
LinkDB: W5PP08_SHEEP
Original site: W5PP08_SHEEP 
ID   W5PP08_SHEEP            Unreviewed;      1327 AA.
AC   W5PP08;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   12-SEP-2018, entry version 21.
DE   SubName: Full=Fanconi anemia complementation group I {ECO:0000313|Ensembl:ENSOARP00000012184};
GN   Name=FANCI {ECO:0000313|Ensembl:ENSOARP00000012184};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012184, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000012184, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012184};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000012184}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AMGL01041419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOART00000012360; ENSOARP00000012184; ENSOARG00000011362.
DR   GeneTree; ENSGT00390000005855; -.
DR   OMA; ANETFCL; -.
DR   OrthoDB; EOG091G03X7; -.
DR   Proteomes; UP000002356; Chromosome 18.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   CDD; cd11720; FANCI; 1.
DR   InterPro; IPR026171; FANCI.
DR   InterPro; IPR029310; FANCI_HD1.
DR   InterPro; IPR029312; FANCI_HD2.
DR   InterPro; IPR029308; FANCI_S1.
DR   InterPro; IPR029305; FANCI_S1-cap.
DR   InterPro; IPR029315; FANCI_S2.
DR   InterPro; IPR029313; FANCI_S3.
DR   InterPro; IPR029314; FANCI_S4.
DR   PANTHER; PTHR21818; PTHR21818; 1.
DR   Pfam; PF14679; FANCI_HD1; 1.
DR   Pfam; PF14680; FANCI_HD2; 1.
DR   Pfam; PF14675; FANCI_S1; 1.
DR   Pfam; PF14674; FANCI_S1-cap; 1.
DR   Pfam; PF14676; FANCI_S2; 1.
DR   Pfam; PF14677; FANCI_S3; 1.
DR   Pfam; PF14678; FANCI_S4; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN        1     53       FANCI_S1-cap. {ECO:0000259|Pfam:PF14674}.
FT   DOMAIN       64    280       FANCI_S1. {ECO:0000259|Pfam:PF14675}.
FT   DOMAIN      284    369       FANCI_HD1. {ECO:0000259|Pfam:PF14679}.
FT   DOMAIN      377    540       FANCI_S2. {ECO:0000259|Pfam:PF14676}.
FT   DOMAIN      554    782       FANCI_HD2. {ECO:0000259|Pfam:PF14680}.
FT   DOMAIN      801   1025       FANCI_S3. {ECO:0000259|Pfam:PF14677}.
FT   DOMAIN     1039   1288       FANCI_S4. {ECO:0000259|Pfam:PF14678}.
SQ   SEQUENCE   1327 AA;  149364 MW;  62867B8DD849A771 CRC64;
     MDQKILSLAA EKTADGLQEF LQTVKEDDLT DLLQNQAVKG KAAGALLKAI FKGLPCSEEA
     GALKRLKIYS CCIQLLESGD LQKEVASEII GLLMLEVHRF PGQLLVELAN EFVSAISEGK
     LTNGKSLELL PIILTALGTK KENLTFGKGE LSGEECKKQL INTLCSGRWD HQYVIRLTSM
     FKAVPLTAEE VEFVVEKVFK VFSKLNLQEI PPLVYQLLVL SSKGSRKRVL GGIIAFFNKL
     DQQHNEEKSD DEYLDLVTVP LDELRHVEGT IILHIVFAIK LDFELGRELL KHLKAAQQGD
     FSSICPFSIA LLLSVTRIQR FEEQVFDFLK SSVIKSFKDL QLLQGSKYIQ NLFPHGYCIS
     TMILEVVNNS VHSWDHVTQG LVEFGFLLMD SYGPKRIPDG KTAETSSGLS RMPNQHACKL
     GADILLETFK IHEMIRQEIL EQVLNRVVTR ASSPISHFLD LLSDIIKYSP LVLQSCSSKV
     IETFDYLSFL PVQTVQGLLK AVQPLLKVSM SIRDSLILVL RKAMFASQLD ARKSAVAGFL
     LLLKNFKVLG SLSSSQCSQS IGVSQVHVDI HSRYNSVANE TFCLEIMDSL KRCLGQQADV
     RLMLYEGFYD VLRRNSQLAN SVMQTLLSQL KQFYEPEPDV LPPLKLEACI LTQGDQVSLQ
     EPLDYLLCCI QHCLAWYKSR VVPLQQEEEE EEEGFYQYLD DMLESITNRM IKSELEDFEL
     DKSADFSQST GIGIKNNICA SLVMGICEVL IEYNFFISNF SKTKFETILS LFMCYKKLSD
     ILNEKSGKGK TKMANRTTDS FLSMKFVSDL LTALFRDSTQ SHEESLSVLR SSNEFMRYAV
     NVALQKVQQL KETGHVSGPD GQNPEKVFQH LCDITRVLLW RYTSIPTSVE ESGKKEKGKN
     ISLLCLEGIQ KILSAVQQFY QPKCHQFLKA LVDATDEEEE EVSVSQRAAF QIRQFQRSLL
     NLLSSQEEDF KSKEALLLAT VLTSLSKLLK PISAEFVQML TWTSKICTEN SCEDASFCKG
     MLSLLFNLHV SYKSPVSLLR DLSQDIHGHL GDIDEDVEVE KTNNFALVNL KTAAPTVCLL
     VLSKAEKVLE EVDWLITKLK GQANQKIVSE EASSQAALTN HPMEKTTIIQ LGTLLTFFHE
     LVQTALPSGS CVDTLLKDLC KMYTTLTALV KYYLQVYQRP TGIPKNMEKL VKLSGSHLTP
     LCYSFISYVQ NKHSKSLKCT GEKEKTAAGP TAMARALRET KPIPNLIFAI EQYEKFLIHL
     SKRSKVNLMK HIKLSTSRDF KIKGNVLDAV LRQEEEDENE EGTASEHEGQ NKEPAKKKRK
     KEKKCLS
//
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