ID W5PPV8_SHEEP Unreviewed; 703 AA.
AC W5PPV8; A0A6P3E224;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=SH2 domain-containing protein 3C {ECO:0008006|Google:ProtNLM};
GN Name=SH2D3C {ECO:0000313|Ensembl:ENSOARP00000012485.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012485.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012485.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012485.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012485.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01074853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01074854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01074855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01074856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01074857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004005669.1; XM_004005620.3.
DR AlphaFoldDB; W5PPV8; -.
DR Ensembl; ENSOART00000012668.1; ENSOARP00000012485.1; ENSOARG00000011649.1.
DR GeneID; 101102214; -.
DR CTD; 10044; -.
DR HOGENOM; CLU_015281_0_0_1; -.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000011649; Expressed in leukocyte and 51 other cell types or tissues.
DR ExpressionAtlas; W5PPV8; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
SQ SEQUENCE 703 AA; 77093 MW; 877F21327640E555 CRC64;
MTAVGRRCPA LGSRGATAEP EAGGDYVKFS KEKYILDSSP EKLHKELEEE LKLSSTDLRS
HAWYHGRIPR EVSETLVQRN GDFLIRDSLT SLGDYVLTCR WRNQALHFKI NKVVVKAGES
YTHIQYLFEQ ESFDHVPALV RYHVGSRKAV SEQSGAIIYC PVNRTFPLRY LEACYGLGQG
GGKAASPASP SGPKGSHMKR RSVTMTDGLT ADKVTRSDGC PTSTSLPHPR ESIRNCALSM
DQIQDLHSPM SPISESPSSP AYSTVTRVHA APAAPSTTAL PASPVTRRSS EPQLCPGSAP
KPHGESDKGP YSSPSHTLCK ASPSPSLSSY SDPDSGHYCQ LQPPVRGSRE WVAAEASGRQ
ARSYGEKLKE LSENGAPEGD WGRTFTVPVV EATSSFNPAT FQSLLIPKDN RPLEVGLLRK
VKELLAEVDA RTLARHVTKV DCLVARILGV TKEMQTLMGV RWGMELLTLP HGRQLRLDLL
ERFHTMSIML AVDILGCTGS AEERAALLHK TIQLAAELRG TMGNMFSFAA VMGALDMAQI
ARLEQTWVTL RQRHTEGAIL YEKTLKPFLK SLNEGKEGPP LSNTTFPHIL PLITLLECDT
APAEGPEPWG STEHGVEVVL AHLEAARTVA HHGGLYHTNA EVKLQGFQAR PELLEVFSTE
FQMRLLWGSQ GASSSQARRY EKFDKVLTAL SHKLEPAIRS SEL
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