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Database: UniProt
Entry: W5PQA5_SHEEP
LinkDB: W5PQA5_SHEEP
Original site: W5PQA5_SHEEP 
ID   W5PQA5_SHEEP            Unreviewed;       375 AA.
AC   W5PQA5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-OCT-2019, entry version 31.
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 14 {ECO:0000313|Ensembl:ENSOARP00000012632};
GN   Name=KCNJ14 {ECO:0000313|Ensembl:ENSOARP00000012632};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012632, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000012632, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012632,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000012632}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMGL01029288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01029289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9940.ENSOARP00000012632; -.
DR   Ensembl; ENSOART00000012818; ENSOARP00000012632; ENSOARG00000011788.
DR   GeneTree; ENSGT00960000186595; -.
DR   Proteomes; UP000002356; Chromosome 14.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     30     54       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     61       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      172    308       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      339    375       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   375 AA;  40878 MW;  376795FF286BC9D8 CRC64;
     CNVRFVNLGG QGARYLSDLF TTCVDVRWRW MCLLFSCSFL ASWLLFGLAF WLIASLHGDL
     TAPPPPPPRF SLRVCPGAGH APWWAGPSAR SGSGSRGVGG SCRSTEQVLL LREVQNCGQT
     AQTNSGAVAA PAPVKTLKLN AGLGLDLDEK RTGLWWELQL PAASSFLLSL ATCLLLQPRV
     TPEGEYIPLD HQDVDVGFDG GTDRIFLVSP ITIVHEIDSA SPLYELGRAE LARADFELVV
     ILEGMVEATA MTTQCRSSYL PGELLWGHRF EPVLFQRGSQ YEVDYRHFHR TYEVPGTPVC
     SAKELDERAE RASQSPKSGF PSSLAAFCYE NELALSCCQE EDEEEEATEG DAAEAEDKAA
     SPQVLTPTLA LTLPP
//
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