ID W5PQT0_SHEEP Unreviewed; 887 AA.
AC W5PQT0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Tight junction protein ZO-3 {ECO:0008006|Google:ProtNLM};
GN Name=TJP3 {ECO:0000313|Ensembl:ENSOARP00000012807.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012807.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012807.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012807.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AMGL01091621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01091622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PQT0; -.
DR SMR; W5PQT0; -.
DR STRING; 9940.ENSOARP00000012807; -.
DR PaxDb; 9940-ENSOARP00000012807; -.
DR Ensembl; ENSOART00000012994.1; ENSOARP00000012807.1; ENSOARG00000011941.1.
DR eggNOG; KOG3580; Eukaryota.
DR HOGENOM; CLU_006234_0_0_1; -.
DR OMA; MEEVTIW; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000011941; Expressed in descending colon and 49 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005420; ZO-3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF11; TIGHT JUNCTION PROTEIN ZO-3; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01600; ZONOCCLUDNS3.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 11..79
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 167..244
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 347..413
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 442..516
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 627..729
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 92..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 97676 MW; 71C229111F837340 CRC64;
MEELTIWEQC TATISKDPRR GFGIAISGGR DRSGGSVVVS DVVPGGPAEG WLQTGDHIVM
VNGVSMESVT STFAIQILKT CTKMANIKRP RKVQVPATKV TSAPGHQDSD EEDRLRHLEE
ADHGRGYDGD TSSGSGHSWG SEVNALARVS GFKRLPRQDV QMRPVKSVLV RKRESDDFGV
KLGSQIFIKH ITDSGLAAQN SGLQEGDLIL QINGVSSENL SLSDTRQLIE KSEGKLTLLV
LRDRGQFLVN IPPAVSDSDS SLLEDISDLG SELSQAPPSH IPPPPQHGQQ SPDTSRTNSP
VESHRLRRES SVDSRTTSEP DSPRPRNYDI YRVSSGQSVE DDGYSPDSRV VRFFKGTNIG
LRLAGGNDVG IFVSGVQAGS PADGQGILEG DEILQVNDTP FQNLTREEAV NFLLGLPVGE
EVELVTQRKQ DIFQKMVRSG LGDSFYIRTH FEMEPSPPSG LGFTRGDVFH VLDTLYPGPG
QSPARGGQWL AVRMGRDLRE KERGIIPNQS RAEQLASLEA AQRAVGVIPG ASAGSNSRAE
FWRLRGLRRG AKKTTHRSRE DLSALTKQGH YPPYERVVLR EASFKRPVVI LGPVADIAMQ
KLTAEMPDKF EIAESVSRTE SPSKIIRLDT VRVIAEQDKH ALLDVTPSAI ERLNYVQYYP
IVVFFCVPES RTALKPLRQW LAPASRRSSR RLYAQAQKLR KYSDHLFTAT IPLQGTSDSW
YQELKAVIQE QQTRPIWTAE DQLDSSSEDN LDLPHHGLAD SSADLSCDSR VNSDYETDGE
GSVYTDGEGY TDGEGGPHTD VDEGPRVPAL ARSSEPVLGD EPRIPQDHGR PSGPRGAQMD
SRHPQGQRRQ DSMRTYEREA LRKKFTRARD VESSDEDGYD WGPATDL
//
