ID W5PR79_SHEEP Unreviewed; 244 AA.
AC W5PR79;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Keratin-associated protein 10-12-like {ECO:0008006|Google:ProtNLM};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000012957.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000012957.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000012957.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000012957.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000256|ARBA:ARBA00003327}.
CC -!- FUNCTION: The keratin products of mammalian epidermal derivatives such
CC as wool and hair consist of microfibrils embedded in a rigid matrix of
CC other proteins. The matrix proteins include the high-sulfur and high-
CC tyrosine keratins, having molecular weights of 6-20 kDa, whereas the
CC microfibrils contain the larger, low-sulfur keratins (40-56 kDa).
CC {ECO:0000256|ARBA:ARBA00003914}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000256|ARBA:ARBA00011662}.
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DR EMBL; AMGL01012128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01012134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PR79; -.
DR Ensembl; ENSOART00000013146.1; ENSOARP00000012957.1; ENSOARG00000012089.1.
DR HOGENOM; CLU_062832_0_0_1; -.
DR OMA; DSCCEPP; -.
DR Proteomes; UP000002356; Chromosome 1.
DR ExpressionAtlas; W5PR79; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; KERATIN ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23262:SF50; KERATIN-ASSOCIATED PROTEIN 10-4-RELATED; 1.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 4: Predicted;
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
SQ SEQUENCE 244 AA; 25393 MW; F1B1153FD435BCB1 CRC64;
MAFSTLSACS SDLSYSSRVC LPGSCDSCTG SSWAEDDCPE SCCEPPCCAP SCCALAPRLT
LLCAPVSCES SLCCQPACNS SCPASCCQQS SCQPTCCTSS PCQQACCEPV CCRPVCYTPV
CCTPVCCRPV CCRPVCCRPV CCRPVCCTPV CCRPVCCRPV CCTPVCCRPV CCEASPCLAP
SSCCRPSSSV SLLCRPVCRP TCCVPDSSCQ PSCCRPASSV SLLCRPVCSR PACCIPTLAP
EPCC
//
