GenomeNet

Database: UniProt
Entry: W5PRH3_SHEEP
LinkDB: W5PRH3_SHEEP
Original site: W5PRH3_SHEEP 
ID   W5PRH3_SHEEP            Unreviewed;       245 AA.
AC   W5PRH3;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   Name=EIF6 {ECO:0000256|HAMAP-Rule:MF_03132,
GN   ECO:0000313|Ensembl:ENSOARP00000013052.1};
GN   Synonyms=ITGB4BP {ECO:0000256|HAMAP-Rule:MF_03132};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013052.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000013052.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013052.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000013052.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Behaves as a stimulatory translation
CC       initiation factor downstream insulin/growth factors. Is also involved
CC       in ribosome biogenesis. Associates with pre-60S subunits in the nucleus
CC       and is involved in its nuclear export. Cytoplasmic release of TIF6 from
CC       60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-
CC       dependent protein kinase C activity. In tissues responsive to insulin,
CC       controls fatty acid synthesis and glycolysis by exerting translational
CC       control of adipogenic transcription factors such as CEBPB, CEBPD and
CC       ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-
CC       dependent megakaryocyte maturation and platelets formation, controls
CC       the expression of mitochondrial respiratory chain genes involved in
CC       reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated
CC       gene silencing by the RNA-induced silencing complex (RISC). Required
CC       for both miRNA-mediated translational repression and miRNA-mediated
CC       cleavage of complementary mRNAs by RISC. Modulates cell cycle
CC       progression and global translation of pre-B cells, its activation seems
CC       to be rate-limiting in tumorigenesis and tumor growth.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit. Interacts
CC       with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they
CC       form a large RNA-induced silencing complex (RISC). {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMGL01025924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PRH3; -.
DR   SMR; W5PRH3; -.
DR   STRING; 9940.ENSOARP00000013052; -.
DR   PaxDb; 9940-ENSOARP00000013052; -.
DR   Ensembl; ENSOART00000013241.1; ENSOARP00000013052.1; ENSOARG00000012174.1.
DR   eggNOG; KOG3185; Eukaryota.
DR   HOGENOM; CLU_071894_0_0_1; -.
DR   OMA; GCRIVGR; -.
DR   Proteomes; UP000002356; Chromosome 13.
DR   Bgee; ENSOARG00000012174; Expressed in omasum and 51 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:cytosolic ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   NCBIfam; TIGR00323; eIF-6; 1.
DR   PANTHER; PTHR10784; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   PANTHER; PTHR10784:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   SUPFAM; SSF55909; Pentein; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
FT   MOD_RES         165
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
SQ   SEQUENCE   245 AA;  26644 MW;  D0B1071D25402243 CRC64;
     MAVRASFENN CEIGCFAKLT NSYCLVAIGG SENFYSVFEG ELAGTIPVVH ASIAGCRIIG
     RMCVGNRHGL LVPNNTTDQE LQHIRNCLPD SVQIRRVEER LSALGNVTTC NDYVALVHPD
     LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP
     LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAQPS TIATSMRDSL
     IDRYL
//
DBGET integrated database retrieval system