ID W5PRV3_SHEEP Unreviewed; 771 AA.
AC W5PRV3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Groucho/TLE N-terminal Q-rich domain-containing protein {ECO:0000259|Pfam:PF03920};
GN Name=TLE1 {ECO:0000313|Ensembl:ENSOARP00000013182.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013182.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013182.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013182.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013182.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR EMBL; AMGL01049075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01049076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PRV3; -.
DR SMR; W5PRV3; -.
DR STRING; 9940.ENSOARP00000013182; -.
DR PaxDb; 9940-ENSOARP00000013182; -.
DR Ensembl; ENSOART00000013376.1; ENSOARP00000013182.1; ENSOARG00000012299.1.
DR eggNOG; KOG0639; Eukaryota.
DR HOGENOM; CLU_007612_3_0_1; -.
DR OMA; CAVMINS; -.
DR Proteomes; UP000002356; Chromosome 2.
DR Bgee; ENSOARG00000012299; Expressed in uterus and 54 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF29; TRANSDUCIN-LIKE ENHANCER PROTEIN 1; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 18..133
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 571..612
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 613..654
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 128..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..53
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 140..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 83295 MW; 68F7C09AB518A44D CRC64;
LYPTARIPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK
DDKKHHDAEH HRDREPGTSN SLLVPDSLRA TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD
GDKSDDNLVV DVSNEEDPSS PRASPAHSPR ENGIDKTRLL KKDASSSPAS TASSGSSTSL
KSKEMSLHEK ASTPVLKSST PTPRSDMPTP GTSATPGLRP GLGKPPAMDP LVNQAAPGLR
TPLAVPGPYP APFGMVPHAG MNGELTSPSA AYASLHNMSP QMSAAAAAAA VVAYGRSPMV
GFDPPPHMRV PTIPPNLAGI PGGKPAYSFH VTADGQMQPV PFPPDALIGP GIPRHARQIN
TLSHGEVVCA VTISNPTRHV YTGGKGCVKV WDISHPGNKS PVSQLDCLNR DNYIRSCKLL
PDGCTLIVGG EASTLSIWDL AAPTPRIKAE LTSSAPACYA LAISPDSKVC FSCCSDGNIA
VWDLHNQTLV RQFQGHTDGA SCIDISNDGT KLWTGGLDNT VRSWDLREGR QLQQHDFTSQ
IFSLGYCPTG EWLAVGMESS NVEVLHVNKP DKYQLHLHES CVLSLKFAYC GKWFVSTGKD
NLLNAWRTPY GASIFQSKES SSVLSCDISV DDKYIVTGSG DKKATVYEVI Y
//
