ID   W5PSJ2_SHEEP            Unreviewed;       760 AA.
AC   W5PSJ2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=U3 small nucleolar RNA-associated protein 25 homolog {ECO:0000256|ARBA:ARBA00024421};
DE   AltName: Full=UTP25 small subunit processor component {ECO:0000256|ARBA:ARBA00032325};
GN   Name=UTP25 {ECO:0000313|Ensembl:ENSOARP00000013421.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013421.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000013421.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013421.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000013421.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the UTP25 family.
CC       {ECO:0000256|ARBA:ARBA00009223}.
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DR   EMBL; AMGL01022777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01022778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5PSJ2; -.
DR   STRING; 9940.ENSOARP00000013421; -.
DR   PaxDb; 9940-ENSOARP00000013421; -.
DR   Ensembl; ENSOART00000013618.1; ENSOARP00000013421.1; ENSOARG00000012524.1.
DR   eggNOG; KOG2340; Eukaryota.
DR   HOGENOM; CLU_018705_1_1_1; -.
DR   OMA; KYFRQTI; -.
DR   Proteomes; UP000002356; Chromosome 12.
DR   Bgee; ENSOARG00000012524; Expressed in conceptus and 53 other cell types or tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0034511; F:U3 snoRNA binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010678; UTP25.
DR   PANTHER; PTHR12933; ORF PROTEIN-RELATED; 1.
DR   PANTHER; PTHR12933:SF0; U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG; 1.
DR   Pfam; PF06862; UTP25; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   REGION          47..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..125
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  87050 MW;  C3E019D57720A682 CRC64;
     MGKRGSRLSS VWHFLAIPAQ VHMEFLHDYG YNYLFLLRVS RKEAKPQTCQ LSESSDTSSS
     ESEAESEPEQ VSGYHRLLAT LKNVSKEEEE EEEEEEEEDS VTDETEMNLE DGDSDISEEE
     EMAAESADMQ GSVASPADPE GKDGHGPPGT SEESPEEFTD AKHESLFSLE TNFLEEESGG
     DSSLKASQGL DPFVQHVNTK LKEKEIQAVA TNPRTTHQLK WPILGQVVFS SKFQKLETFK
     PPKDIDLKSV HLQKPLESTW IKTNSQFLSG PQKSSSPFTP LQKELFLIMN SYRDLFYPER
     TALKNGEEIR HVYCLHVINH VLKANAQVLA NNSRRRSQKL GVGDDDDFRD QGLTRPKVLI
     VVPFREAALR VVQLFISLLE GDSKKKIIVS NKKRFNGEYG SDPEERPPNL KRPEDYEAVF
     VGNIDDHFRI GVAILQRSIR LYAPFYSSDI LIASPLGLRT IIGGEGEKKR DFDFLSSVEL
     LIIDQADIYL MQNWEHVLHL MNHMNLLPLD SHGVDFSRVR MWSLNNWSKY YRQTLLFGAL
     QDAQINSVFN KYCVNVQGQV AVRNVPMTGS ISQVLVQLPH VFQRMEAESL SSVIDASRFN
     FFVNKILPQY RDAVMSHTLI YVPSYFDFVR LRNYFKKEEL NFTHICEYTQ KSGVSRARHF
     FLQGEKQFLL LTERFHFYKR YTIKGIRNLI FYELPTYPHF YSEVCNMLRA TGSGEEAAWT
     CTVLYSKYDA QRLAAVVGVE RAAQMLQSKK NVHLFITGER
//