ID W5PSJ9_SHEEP Unreviewed; 1190 AA.
AC W5PSJ9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ribonuclease III {ECO:0000256|ARBA:ARBA00012177};
DE EC=3.1.26.3 {ECO:0000256|ARBA:ARBA00012177};
GN Name=DROSHA {ECO:0000313|Ensembl:ENSOARP00000013428.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013428.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013428.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013428.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013428.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000109};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01035338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01035339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01035340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011952522.1; XM_012097132.1.
DR AlphaFoldDB; W5PSJ9; -.
DR SMR; W5PSJ9; -.
DR STRING; 9940.ENSOARP00000013428; -.
DR PaxDb; 9940-ENSOARP00000013428; -.
DR Ensembl; ENSOART00000013625.1; ENSOARP00000013428.1; ENSOARG00000012525.1.
DR GeneID; 101115827; -.
DR KEGG; oas:101115827; -.
DR CTD; 29102; -.
DR eggNOG; KOG1817; Eukaryota.
DR HOGENOM; CLU_004383_0_0_1; -.
DR OMA; ENFTIHE; -.
DR OrthoDB; 5486676at2759; -.
DR Proteomes; UP000002356; Chromosome 16.
DR Bgee; ENSOARG00000012525; Expressed in cerebellum and 54 other cell types or tissues.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd19877; DSRM_RNAse_III_meta_like; 1.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR HAMAP; MF_00104; RNase_III; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR044442; RNAse_III_DSRM__animal.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR11207:SF0; RIBONUCLEASE 3; 1.
DR PANTHER; PTHR11207; RIBONUCLEASE III; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF14622; Ribonucleas_3_3; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS00517; RNASE_3_1; 2.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 692..872
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 923..1049
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1076..1150
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 1..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..309
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1190 AA; 138300 MW; 0126E504C028B790 CRC64;
MMPPPSLPHP PPPPVVPQQV NYQYPPGYSH HSFPPPNFSS FQNSPSSFPP SASNSSSPHF
RHLPPYPLPK APSERRSPER LKHYDDHRHR DHSHGRGERG GGGGGGGPPD GRRQDSRYRS
DHERGRTPSR HRSYERSRER ERERHRHRDS RRSPSLERSY KKEYKRSGSR SPSREKKRAR
WEEEKDRWSD IQGSGKEKNY TSIKEKEPEE ALPDKNEEEE EELLKPVWIR CTHSENYYSS
DPMDQVGDST VVGTSRLRDL YDKFEEELGS RQEKAKAARP PWEPPKTKLD EDLESSSESE
CESDEDSTCS SSSDSEVFDV IAEIKRKKAH PDRLHDELWY NDPGQMNDGP LCKCSAKARR
TGIRHSIYPG EEAIKPCRPM TNNAGRLFHY RITVSPPTNF LTDRPTVIEY DDHEYIFEGF
SMFAHAPLTN IPLCKVIRFN IDYTIHFIEE MMPENFCVKG LELFSLFLFR DILELYDWNL
KGPLFEDSPP CCPRFHFMPR FVRFLPDGGK EVLSMHQILL YLLRCSKALV PEEEIANMLQ
WEELEWQKYA EECKGMIVTN PGAKPSSVRI DQLDREQFNP DVITFPIIVH FGIRPAQLSY
AGDPQYQKLW KSYVKLRHLL ANSPKVKQTD KQKLAQREEA LQKIRQKNTM RREVTVELSS
QGFWKTGIRS DVCQHAMMLP VLTHHIRYHQ CLMHLDKLIG YTFQDRCLLQ LAMTHPSHHL
NFGMNPDHAR NSLSNCGIRQ PKYGDRKVHH MHMRKKGINT LINIMSRLGQ DDPTPSRINH
NERLEFLGDA VVEFLTSVHL YYLFPSLEEG GLATYRTAIV QNQHLAMLAK KLELDRFMLY
AHGPDLCRES DLRHAMANCF EALIGAVYLE GSLEEAKQLF GRLLFNDPDL REVWLNYPLH
PLQLQEPNTD RQLIETSPVL QKLTEFEDAI GVIFTHVRLL ARAFTLRTVG FNHLTLGHNQ
RMEFLGDSIM QLVATEYLFI HFPDHHEGHL TLLRSSLVNN RTQAKVAEEL GMQEYAITND
KTKRPVALRT KTLADLLESF IAALYIDKDL EYVHTFMNVC FFPRLKEFIL NQDWNDPKSQ
LQQCCLTLRT EGKEPDIPLY KTLQTVGPSH ARTYTVAVYF KGERIGCGKG PSIQQAEMGA
AMDALEKYNF PQMAHQKRFI ERKYRQELKE MRWEREHQEK EPDETEDIKK
//
