ID W5PT68_SHEEP Unreviewed; 2640 AA.
AC W5PT68;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN Name=FLNB {ECO:0000313|Ensembl:ENSOARP00000013649.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013649.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013649.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013649.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AMGL01045367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045371; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5PT68; -.
DR STRING; 9940.ENSOARP00000013649; -.
DR PaxDb; 9940-ENSOARP00000013649; -.
DR Ensembl; ENSOART00000013853.1; ENSOARP00000013649.1; ENSOARG00000012724.1.
DR eggNOG; KOG0518; Eukaryota.
DR HOGENOM; CLU_000783_0_0_1; -.
DR OMA; RAVPCKV; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000012724; Expressed in rectum and 53 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21309; CH_FLNB_rpt1; 1.
DR CDD; cd21313; CH_FLNB_rpt2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 16..122
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 139..242
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 249..347
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 349..446
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 447..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 544..636
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 640..736
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 737..839
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 837..935
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 936..1031
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1032..1124
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1125..1224
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1225..1324
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1325..1420
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1421..1547
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1548..1644
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1645..1740
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1745..1854
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1854..1946
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1957..2032
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2035..2127
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2125..2223
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2226..2318
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2320..2413
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2417..2509
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2545..2639
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 244..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2640 AA; 282409 MW; 4C557CAB5E6539E7 CRC64;
MPVTEKDLAE DAPWKKIQQN TFTRWCNEHL KCVNKRIGNL QTDLSDGLRL IALLEVLSQK
HMYRKYHQRP TFRQMQLENV SVALEFLDRE SIKLVSIDSK AIVDGNLKLI LGLVWTLILH
YSISMPVWED EGDDDAKKQT PKQRLLGWIQ NKIPYLPITN FNQNWQDGKA LGALVDSCAP
GLCPDWESWD PRKPVDNARE AMQQADDWLG VPQVITPEEI IHPDVDEHSV MTYLSQFPKA
KLKPGAPLKP KLNPKKARAY GRGIEPTGNM VKQPAKFTVD TISAGQGDVM VFVEDPEGNK
EEALVTPDSD KNKTYSVEYL PKVTGLHKVT VLFAGQHISK SPFEVNVDKA QGDASKVTAK
GPGLEAAGNI ANKPTYFDIY TAGAGVGDIG VEVEDPQGKN TVELLVEDRG NQVYRCVYKP
MQPGPHVVKV SFAGDTIPKS PFVVQVGEAC NPNACRASGR GLQPKGIRIR ETADFRVDTK
AAGSGELGVT IKGPKGLEEL VKQKGFQDGV YAFEYYPSTQ GKYSISITWG GHHIQKSPFE
VQVGPEAGMQ KVRAWGPGLH GGIVGRSADF VVESIGSEVG SLGFAIEGPS QAKIEYDDQN
DGSCDVKYWP KEPGEYAVHI MCDDEDIKDS PFMAYIHPAS GDYNPDLVQA YGPGLEKSGC
IVNNLAEFTV DPKDAGKAPL KIFAQDGDGQ PIDIQMKSRM DGTYACSYTP VKAIKHTIAV
VWGGVNIPHS PYRVSIGQGS HPQKVKVFGP GVERSGLKAQ EPTHFTVDCT EAGEGDVSVG
IKCDARVLSD EEEDVDFDII HNANDTFTVK YVPPAAGRYT IKVLFASQEI PTSPFRVKVH
DASKVKAEGP GLSKAGVENG KPTHFTVYTK GAGKAPLNVQ FSSPGPGDAV KDLDIIDNYD
YSHTVKYTPT QQGNMQVLVT YGGDPIPKSP FTVGVAAPLD LSRIKINGLE NRVEVGKDQE
FAVDTRGAGG QGKLDVTILS PSRKVVPCLV APVAGRESST AKFIPREEGL YAIDLTYDGH
PVPGSPYMVE ASLPPDPTKV KAHGPGLKGG LVGKPAEFTI DTKGAGTGGL GLTVEGPCEA
KIECSDNGDG TCSVSYLPTK PGEYFVNILF EEVHIPGSPF KADIEMPFDP SKVVASGPGL
EHGKVGEAGL LSVDCSEAGP GTLGLEAVSD SGAKAEVCIE NNKDGTYAVT YVPLTAGMYT
LTMKYGGGLV PHFPTRGQPT RVKVEPAVDT SRVKVFGPGI EGKDVFREAT TDFTVDSRPL
TQVGGDHIKA HIANPSGAST ECFVTDNADG TYQVEYTPFE KGLHVVEVTY DDVPVPNSPF
KVAVTEGCQP SRVQAQGPGL KEAFTNKPNV FTVVTRLRRG AGIGGLGITV EGPSESKINC
RDNKDGSCSA EYVPFAPGDY DVNITYGGAH IPGSPFRVPV KDVVDPSKVK IVGPGLGSGV
RARVLQSFTV DSSKAGLAPL EVRVMGPRAD QRIPWSRRSP LQAISGFFKR DRKGDFMETG
LVEPVNVVDN GDGTHTVTYT PSQEGPYMVS VKYADEEIPR SPFKVKVLPT YDASKVTASG
PGLSTYGVPA SLPVEFAIDA RDAGEGLLAV QITDQEGKPK RAIVHDNKDG TYAVTYIPDK
TGRYMIGVTY GGDDIPLSPY RIRATQTGDA SKCLATGPGI ASTVKTGEEV GFVVDAKTAG
KGKVTCTVLT PDGTEAEADV IENEDGTYDI FYTAAKPGTY VIYVRFGGVD IPNSPFTVMA
TDGEVAAVKE VPVNACPPGF RPWVTEEAYV PVSNMNGLGF KPFDLVIPFA VRKGEITGEV
HMPSGKTATP EIVDNKDGTV TVRYAPTEVG LHEMHIKYMG SHIPDPESPL QFYVNYPNSG
SVSAYGPGLV YGVANKTATF TIVTEDAGEG GLDLAIEGPS KAEISCIDNK DGTCTVTYLP
TLPGDYSILV KYNDKHIPGS PFTAKITDDN RRCSQVKLGS AADFLLDISE TDLSTLTASI
KAPSGRDEPC LLKRLPNNHI GISFIPREVG EHLVSIKKNG NHVANSPVSI MVVQSEIGDA
RRAKVYGRGL SEGRTFEMSD FIVDTRDAGY GGISLAVEGP SKVDIQTEDL EDGTCKVSYF
PTVPGVYIVS TKFADEHVPG SPFTVKISGE GRVKESITRT SRAPSAATVG SICDLNLKIP
EIDSSDMSAH VTSPSGRVTE AEIVPVGKNS HCVRFVPQEM GVHTVTVKYR GQHVTGSPFQ
FTVGPLGEGG AHKVRAGGPG LERGEAGVPA EFSIWTREAG AGGLSIAVEG PSKAEITFDD
HKNGSCGVSY IAQEPGNYEV SIKFNDEHIP ESPYVVPVIA PSDDARRLTV LSLQESGLKV
NQPASFAIRL NGAKGKIDAK VHSPSGAVEE CHVSELEPDK YAVRFIPHEN GVHTIDVKFN
GSHVVGSPFK VRVGEPGQAG NPALVSAYGA GLEGGSTGIQ SEFFINTTRA GPGTLSVTIE
GPSKVKMDCQ ETPEGYKVMY TPMAPGNYLI GVKYGGPNHI VGSPFKAKVT GQRLVSPGSA
NETSSILVES VTRSSTETCY SAIPKASSDA SKVTSKGAGL SKAFLGQKSS FLVDCSKAGS
NMLLIGVHGP TTPCEEVSMK HVGNQQYNVT YVVKERGDYV LAVKWGEEHI PGSPFHVTVP
//
