ID W5PTM6_SHEEP Unreviewed; 763 AA.
AC W5PTM6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
GN Name=CPSF2 {ECO:0000313|Ensembl:ENSOARP00000013807.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013807.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013807.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013807.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365006}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC {ECO:0000256|RuleBase:RU365006}.
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DR EMBL; AMGL01042901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PTM6; -.
DR SMR; W5PTM6; -.
DR STRING; 9940.ENSOARP00000013807; -.
DR PaxDb; 9940-ENSOARP00000013807; -.
DR Ensembl; ENSOART00000014012.1; ENSOARP00000013807.1; ENSOARG00000012889.1.
DR eggNOG; KOG1135; Eukaryota.
DR HOGENOM; CLU_002227_1_1_1; -.
DR OMA; YVLEHAW; -.
DR Proteomes; UP000002356; Chromosome 18.
DR Bgee; ENSOARG00000012889; Expressed in testis and 55 other cell types or tissues.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR CDD; cd16293; CPSF2-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR027075; CPSF2.
DR InterPro; IPR025069; Cpsf2_C.
DR InterPro; IPR035639; CPSF2_MBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF13299; CPSF100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU365006};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT DOMAIN 219..349
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
FT REGION 388..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 86364 MW; 176B2480C8A5A79F CRC64;
MTSIIKLTTL SGVQEESALC YLLQVDEFRF LLDCGWDEHF SMDIIDSLRK HVHQIDAVLL
SHPDPLHLGA LPYAVGKLGL NCAIYATIPV YKMGQMFMYD LYQSRHNTED FTLFTLDDVD
AAFDKIQQLK FSQIVNLKDL GKGHGLSITP LPAGHMIGGT IWKIVKDGEE EIVYAVDFNH
KREIHLNGCS LEMLSRPSLL ITDSFNATYV QPRRKQRDEQ LLTNVLETLR GDGNVLIAVD
RLGVYSLALL NNVSYNVVEF SKSQVEWMSD KLMRCFEDKR NNPFQFRHLS LCHGLSDLAR
VPSPKVVLAS QPDLECGFSR DLFIQWCQDP KNSIILTYRT TPGTLARFLI DNPSEKVTEI
ELRKRVKLEG KELEEYLEKE KLKKEAAKKL EQSKEADIDS SDESDAEEDI DQPSAHKTKH
DLMMKGEGSR KGSFFKQAKK SYPMFPAPEE RIKWDEYGEI IKPEDFLVPE LQATEEEKSK
LESGLTNGDE PMDQDLSDVP TKCISTTESI EIKARVTYID YEGRSDGDSI KKIINQMKPR
QLIIVHGPPE ASQDLAECCR AFGGKDIKVY MPKLHETVDA TSETHIYQVR LKDSLVSSLQ
FCKAKDAELA WIDGVLDMRV SKVDTGVILE EGELKDDGED SEMQVDAPSD SSVIAQQKAM
KSLFGDDEKE TGEESEIIPT LEPLPPHEVP GHQSVFMNEP RLSDFKQVLL REGIQAEFVG
GVLVCNNQVA VRRTETGRIG LEGCLCQDFY RIRDLLYEQY AIV
//
