ID W5PTP4_SHEEP Unreviewed; 1723 AA.
AC W5PTP4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Intersectin 1 {ECO:0000313|Ensembl:ENSOARP00000013825.1};
GN Name=ITSN1 {ECO:0000313|Ensembl:ENSOARP00000013825.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013825.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013825.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013825.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013825.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AMGL01005673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01005680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; W5PTP4; -.
DR STRING; 9940.ENSOARP00000013825; -.
DR PaxDb; 9940-ENSOARP00000013825; -.
DR Ensembl; ENSOART00000014030.1; ENSOARP00000013825.1; ENSOARG00000012903.1.
DR eggNOG; KOG1029; Eukaryota.
DR eggNOG; KOG4305; Eukaryota.
DR OMA; YSSMSMT; -.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000012903; Expressed in conceptus and 54 other cell types or tissues.
DR ExpressionAtlas; W5PTP4; baseline.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd13264; PH_ITSN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11989; SH3_Intersectin1_2; 1.
DR CDD; cd11991; SH3_Intersectin1_3; 1.
DR CDD; cd11993; SH3_Intersectin1_4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032140; INTAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF6; GUANINE NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16617; INTAP; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 21..100
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 53..88
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 221..310
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 254..289
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 740..808
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 915..973
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1004..1062
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1076..1140
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1157..1216
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1239..1425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1464..1573
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1581..1697
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 322..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 663..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 355..509
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 565..659
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 330..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1723 AA; 195609 MW; 8BCD6A3A2FA8797B CRC64;
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI
ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV PAAGVPPLAN GAPPVIQPLP AFAHPAATLP
KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL
TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVSEDEQQ QLEKKLPVTF EDKKRENFER
GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE
RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF
ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR
LIPEKQILND QLKQVQQNSL HRDSLLTLKR ALEAKELARQ QLRDQLDEVE KETRSKLQEI
DIFNNQLKEL REMHNKQQLQ KQKSIEAERL KQKEQERKIL ELEKQKEEAQ RRAQERDQQW
LERMHQEDEQ QRPRKPHEEE KLKREESVKK KDSEEKGKPE MQDKLSRLFH QQQEPAKPAV
QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVE VKGEWVDESQ
TGEPGWLGGE LKGKTGWFPA NYAEKIPENE VPAPVKPVTE VASTPTPKVA VRETPAPSTA
TPAEPSETPN NWADFSSTWP ASTNEKPETD SWDAWATQPS LTVPSAGQLR QRSAFTPATA
TGSSPSPVLG QGEKVEGLQA QALYPWRAKK DNHLNFNKND VITVLEQQDM WWFGEVQGQK
GWFPKSYVKL ISGPIRKSTS MDSGSSESPA SLKRVASPAA KPAVSGEEFI AMYTYESSEQ
GDLTFQQGDV ILVTKKDGDW WTGTVGDKSG VFPSNYVRLK DSEGSGTAGK TGSLGKKPEI
AQVIASYTAT GPEQLTLAPG QLILIRKKNP GGWWEGELQA RGKKRQIGWF PANYVKLLSP
GTSKITPTDP LKPTAFPTVC QVIGMYDYTA QNDDELAFSK GQVINVLSKE DPDWWKGEVH
GQVGLFPSNY VKLTPDTDPS QQWCSDLHLL DMLTPTERKR QGYIHELIVT EENYVNDLQL
VTEIFQKPLM ESELLTEKEG AMIFVNWKEL IMCNIKLLKA LRVRKKMSGE KMPVKMIGDI
LTAQLPHMQP YIRFCSCQLN GAALIQQKTD EAPDFKEFVK RLAMDPRCKG MPLSSFILKP
MQRVTRYPLI IKNILENTPE NHPDHSHLKH ALEKAEELCS QVNEGVREKE NSDRLEWIQA
HVQCEGLSEQ LVFNSVTNCL GPRKFLHSGK LYKAKSNKEL YGFLFNDFLL LTQIIKPLGS
SGTDKVFSPK SNLQYKMYKT PIFLNEVLVK LPTDPSGDEP IFHISHIDRV YTLRAESINE
RTAWVQKIKA ASELYIETEK KKREKAYLVR SQRATGIGRL MVNVVEGIEL KPCRSHGKSN
PYCEVTMGSQ CHITKTIQDT LNPKWNSNCQ FFIRDLEQEV LCITVFERDQ FSPDDFLGRT
EIRVADIKKD QGSKGPVTKC LLLHEVPTGE IVVRLDLQLF DEP
//