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Database: UniProt
Entry: W5PTP4_SHEEP
LinkDB: W5PTP4_SHEEP
Original site: W5PTP4_SHEEP 
ID   W5PTP4_SHEEP            Unreviewed;      1723 AA.
AC   W5PTP4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Intersectin 1 {ECO:0000313|Ensembl:ENSOARP00000013825.1};
GN   Name=ITSN1 {ECO:0000313|Ensembl:ENSOARP00000013825.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013825.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000013825.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013825.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000013825.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AMGL01005673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01005680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; W5PTP4; -.
DR   STRING; 9940.ENSOARP00000013825; -.
DR   PaxDb; 9940-ENSOARP00000013825; -.
DR   Ensembl; ENSOART00000014030.1; ENSOARP00000013825.1; ENSOARG00000012903.1.
DR   eggNOG; KOG1029; Eukaryota.
DR   eggNOG; KOG4305; Eukaryota.
DR   OMA; YSSMSMT; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   Bgee; ENSOARG00000012903; Expressed in conceptus and 54 other cell types or tissues.
DR   ExpressionAtlas; W5PTP4; baseline.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd08375; C2_Intersectin; 1.
DR   CDD; cd00052; EH; 2.
DR   CDD; cd13264; PH_ITSN; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11989; SH3_Intersectin1_2; 1.
DR   CDD; cd11991; SH3_Intersectin1_3; 1.
DR   CDD; cd11993; SH3_Intersectin1_4; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 5.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR032140; INTAP.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46006:SF6; GUANINE NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12763; EF-hand_4; 2.
DR   Pfam; PF16617; INTAP; 1.
DR   Pfam; PF16652; PH_13; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 3.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00027; EH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 5.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 5.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50031; EH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   DOMAIN          21..100
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          53..88
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          221..310
FT                   /note="EH"
FT                   /evidence="ECO:0000259|PROSITE:PS50031"
FT   DOMAIN          254..289
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          740..808
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          915..973
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1004..1062
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1076..1140
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1157..1216
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          1239..1425
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          1464..1573
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1581..1697
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          322..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          663..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          820..871
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          977..999
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          355..509
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          565..659
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        330..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        839..871
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        977..992
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1723 AA;  195609 MW;  8BCD6A3A2FA8797B CRC64;
     MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ
     IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI
     ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV PAAGVPPLAN GAPPVIQPLP AFAHPAATLP
     KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL
     TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
     PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVSEDEQQ QLEKKLPVTF EDKKRENFER
     GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE
     RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF
     ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR
     LIPEKQILND QLKQVQQNSL HRDSLLTLKR ALEAKELARQ QLRDQLDEVE KETRSKLQEI
     DIFNNQLKEL REMHNKQQLQ KQKSIEAERL KQKEQERKIL ELEKQKEEAQ RRAQERDQQW
     LERMHQEDEQ QRPRKPHEEE KLKREESVKK KDSEEKGKPE MQDKLSRLFH QQQEPAKPAV
     QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVE VKGEWVDESQ
     TGEPGWLGGE LKGKTGWFPA NYAEKIPENE VPAPVKPVTE VASTPTPKVA VRETPAPSTA
     TPAEPSETPN NWADFSSTWP ASTNEKPETD SWDAWATQPS LTVPSAGQLR QRSAFTPATA
     TGSSPSPVLG QGEKVEGLQA QALYPWRAKK DNHLNFNKND VITVLEQQDM WWFGEVQGQK
     GWFPKSYVKL ISGPIRKSTS MDSGSSESPA SLKRVASPAA KPAVSGEEFI AMYTYESSEQ
     GDLTFQQGDV ILVTKKDGDW WTGTVGDKSG VFPSNYVRLK DSEGSGTAGK TGSLGKKPEI
     AQVIASYTAT GPEQLTLAPG QLILIRKKNP GGWWEGELQA RGKKRQIGWF PANYVKLLSP
     GTSKITPTDP LKPTAFPTVC QVIGMYDYTA QNDDELAFSK GQVINVLSKE DPDWWKGEVH
     GQVGLFPSNY VKLTPDTDPS QQWCSDLHLL DMLTPTERKR QGYIHELIVT EENYVNDLQL
     VTEIFQKPLM ESELLTEKEG AMIFVNWKEL IMCNIKLLKA LRVRKKMSGE KMPVKMIGDI
     LTAQLPHMQP YIRFCSCQLN GAALIQQKTD EAPDFKEFVK RLAMDPRCKG MPLSSFILKP
     MQRVTRYPLI IKNILENTPE NHPDHSHLKH ALEKAEELCS QVNEGVREKE NSDRLEWIQA
     HVQCEGLSEQ LVFNSVTNCL GPRKFLHSGK LYKAKSNKEL YGFLFNDFLL LTQIIKPLGS
     SGTDKVFSPK SNLQYKMYKT PIFLNEVLVK LPTDPSGDEP IFHISHIDRV YTLRAESINE
     RTAWVQKIKA ASELYIETEK KKREKAYLVR SQRATGIGRL MVNVVEGIEL KPCRSHGKSN
     PYCEVTMGSQ CHITKTIQDT LNPKWNSNCQ FFIRDLEQEV LCITVFERDQ FSPDDFLGRT
     EIRVADIKKD QGSKGPVTKC LLLHEVPTGE IVVRLDLQLF DEP
//
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