ID W5PTV8_SHEEP Unreviewed; 361 AA.
AC W5PTV8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN Name=S1PR4 {ECO:0000313|Ensembl:ENSOARP00000013889.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013889.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013889.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013889.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01091655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01091656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PTV8; -.
DR SMR; W5PTV8; -.
DR STRING; 9940.ENSOARP00000013889; -.
DR PaxDb; 9940-ENSOARP00000013889; -.
DR Ensembl; ENSOART00000014095.1; ENSOARP00000013889.1; ENSOARG00000012965.1.
DR eggNOG; ENOG502QQUE; Eukaryota.
DR HOGENOM; CLU_047979_1_1_1; -.
DR OMA; PAHWFLR; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000012965; Expressed in ileocolic lymph node and 45 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038036; F:sphingosine-1-phosphate receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR004064; EDG6_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22750:SF13; SPHINGOSINE 1-PHOSPHATE RECEPTOR 4; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01526; EDG6RECEPTOR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023040};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..284
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 361 AA; 39373 MW; 7700ECB4561184D8 CRC64;
MNATGTPTGD PESCQLLAAG GHSRLVLLHY NHSGRLAGRA GSCGRAPPPS RMRSRRWVYY
CLVNITLSDL LTGAAYLANV LLSGAHTFRL APAQWFLREG LLFMALAAST FSLLFTAGER
FVTMVRPVAE SGATKRGRVC SFIGLCWLLA ALLGLLPLLG WNCVCAFQRC SSLLPLYSKD
YILFCVVVFA FILATIMVLY GAIFRVVRAN GQKAPSTPAR RKARRLLKTV LMILVAFVVC
WGPLFGLLLA DIFGSNVWAQ EYLRGMDWIL ALAVLNSAVN PIIYSFRSRE VCRAVVGFLC
GACLRLGLRG PGDCLAQAVE AHSAASNTDS SLRPRDSFRG SRSHSFRMRE PLTSVSSVRS
V
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