ID W5PU12_SHEEP Unreviewed; 281 AA.
AC W5PU12;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000013943.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000013943.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000013943.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000013943.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000013943.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437}.
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DR EMBL; AMGL01045879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01045880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PU12; -.
DR STRING; 9940.ENSOARP00000013943; -.
DR PaxDb; 9940-ENSOARP00000013943; -.
DR Ensembl; ENSOART00000014149.1; ENSOARP00000013943.1; ENSOARG00000013019.1.
DR eggNOG; ENOG502RWH0; Eukaryota.
DR HOGENOM; CLU_101029_0_0_1; -.
DR OMA; HPGKRFT; -.
DR Proteomes; UP000002356; Chromosome 19.
DR Bgee; ENSOARG00000013019; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 30977 MW; CB7289943C33D992 CRC64;
SAARASSPPP PTPDPESPDR SPGSRTGPRS SCRAAPDAKM PGPWFLLAMA LTLTLTSVPG
GRAQLDVVQQ DVDLSEQQGL EDLLRQAERL LLLREDLQRL REDQDDSASE SQIFQPDWFS
KRQHPGKREE EEADEGVEGE EEEGGAVGLR KRQHPGRRDD VAAWAVDAGQ QKRQHPGRRA
SWLGYAVTKR QHPGRRLVDP RPQRSWEEAG EDEDEGGELM SEKRQHPGKR ALGSPCGPRG
PCGQASLLLG LLDDLSQGQG AEEKRQHPGR RAAWASEPLE E
//
