ID W5PUF8_SHEEP Unreviewed; 1030 AA.
AC W5PUF8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN Name=PITRM1 {ECO:0000313|Ensembl:ENSOARP00000014089.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014089.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014089.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014089.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014089.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; AMGL01025164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01025165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PUF8; -.
DR SMR; W5PUF8; -.
DR STRING; 9940.ENSOARP00000014089; -.
DR PaxDb; 9940-ENSOARP00000014089; -.
DR Ensembl; ENSOART00000014296.1; ENSOARP00000014089.1; ENSOARG00000013136.1.
DR eggNOG; KOG2019; Eukaryota.
DR HOGENOM; CLU_009165_0_0_1; -.
DR OMA; NYLYYIR; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000013136; Expressed in longissimus thoracis muscle and 53 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 504..749
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
SQ SEQUENCE 1030 AA; 115989 MW; EEA2532EAD714AB6 CRC64;
MWRGGWRARD ALRRLSGGGN AHLGAWRWGS TKACERALQY RIGERIHGFT VSQVTPVPEL
SLTAVKLSHD STGAQYLHLA REDRNNLFSV QFRTTPTDSS GTPHILEHTV LCGSQRYPCR
DPFFKMLNRS LSTFMNAFTA SDYTLYPFST QNPKDFQNLL SVYLDAAFFP CLRELDFWQE
GWRLEHEDPN DPQTPLVFKG VVFNEMKGAF TDNERIFSQH LQNRLLPDHT YSVVSGGDPL
CIPDLTWEEL RQFHAVHYHP SNARFFTYGN FPLEQHLKQI HEEALSKFQR IEPRTSVPAQ
KPWDEPREFQ ITCAPDSLAE DPSGQTTISV SFLLPDITDT FEAFTLSLLS SLLISGPNAP
FYKALIESGL GTDFSPDVGY NGCTREAYFS VGLQGIAEKD VQTVRDIVDR TLDDVIEKGF
EEDRIEALLH KIEIQMKHQS VSFGLTLTSY IASCWNHDGD PVELLKLGSQ VAQFRKCLKE
NPRFLQEKVK QYFKNNRHKL TLSMKPDEKY SEKQAQMETE KLQQKVTSLS PEDKQQIYEK
GLELQAQQSQ PPDASCLPAL RVSDVEPRIP LTELEVVQAA GDTPVQYCAQ PTNGVVYFRA
FSSLNALPEE LRPYVPLFCS VLTKLGCGSP DYPELAPPKT GGLAAAPQVL PDDSHLNTYE
QGVLFSSFCL DRNLADMMHL WSEILNDPRL EEEEHFRVLV RMAAQELSNG VPDSGHLYAS
IRAGRTLAPA GDLQETFAGM DQVLLMKRIA EMTNLQPILG NLLRIWKHLL SCDSLRCSVN
ATAQQMSQVE GAVETFLRSL SRSEKEQRPV CLHVVEKPAP KASSGSCPVV RRLVTDPTFE
PCQMKTHFLL PFPVNYVAEC IRTAPYTSPD HASLKILARL MTAKFLHTEI REKGGAYGGG
ARLSYGGMFT LYSYRDPRST ETLQSFMKAI DWAKAGRFTQ QDIDEAKLSV FSAVDAPVAP
SDKGLDHFLY GLSDEMKQVH REQLFAVCHE DLVNVSNRYL GARRNTHGMA LLGPDNASIA
KDPSWVVRQR
//
