ID W5PUR7_SHEEP Unreviewed; 1257 AA.
AC W5PUR7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=C2H2-type domain-containing protein {ECO:0000259|PROSITE:PS50157};
GN Name=ZNF592 {ECO:0000313|Ensembl:ENSOARP00000014199.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014199.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014199.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014199.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014199.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AMGL01041490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PUR7; -.
DR STRING; 9940.ENSOARP00000014199; -.
DR PaxDb; 9940-ENSOARP00000014199; -.
DR Ensembl; ENSOART00000014406.1; ENSOARP00000014199.1; ENSOARG00000013247.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_006283_0_0_1; -.
DR OMA; SVKKYPC; -.
DR Proteomes; UP000002356; Chromosome 18.
DR Bgee; ENSOARG00000013247; Expressed in longissimus thoracis muscle and 52 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR045914; Zn532-like.
DR InterPro; IPR041697; Znf-C2H2_11.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47222; ZINC FINGER PROTEIN 532-RELATED; 1.
DR PANTHER; PTHR47222:SF1; ZINC FINGER PROTEIN 592; 1.
DR Pfam; PF16622; zf-C2H2_11; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 739..766
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 891..919
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1013..1041
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 135738 MW; A673E632950E8676 CRC64;
MGDMKTPDFD DLLAAFDIPD PTSLDAKEAI QTPSEENESP LKPPGLCVDE NVSLSHSGSA
SDVPAVSVIV KNTSRQESFE AEKDHIAPSL LHNGFRGSDL PADPHSLGHN CGKFDSTFMN
GDSTRGFPSK LEASKSEPLP TFNQFSPISS PEPEDAIKDN GFGMKPKHSD SYFPPPPGCG
SVGGPVLEAL TKFPVPELHM FDHFCKKEPK PEPLPLGSPQ EHERGGQKAL EVHKELDASR
FFGDALDFSS HPGNSIGEPK GLASELGTSS AVPPRQRLKP AHSKLSSCVA ALVALQAKRV
ANVAKEDQPS HTKDPSGPAK EGSKSSPKMP KSPKSPRSPL EATRKSIKPS DSPRSICSDS
SSKGSPSVAA SSPPAIPKVR IKTIKTSSGE IKRTVTRILP DPDDPSKSPA GSPLGSATAE
APSEAPEDEA TTLSGVEHFA EVGTQPGSPQ SDRKGEECTA KAREPSPSCF SSGARPKGQS
PAPPASTPAP ANLLPKAVHL ANLNLVPHSV AASVTAKSSA QRRSQPQPTQ MSVPLVHQVK
KAAPLVVEVF NKVLHSSNPV PLYAPNLSPP ADSRIHVPAS GYCCLGGGGA GALEKSLSHL
EKSLSQHYGR RSVHIEVLCT LCSQTLLFFN KCSLLRHARD HKSKGLVMQC SQLLVKPISA
DQMFVSTPVN STAPAAAAPP SPGQAASNAS PPLPALPLYP DPVRLIRHSI KCLECHKQMR
DYMAMAAHFQ RTTEETEGLT CQVCQMLLPN QCSFCAHQRI HAHKSPYCCP ECGALCRSAY
FQTHVKENCL HYAPPLSSRC IHCGVVHLTL ALLKSHIQER HCQVFHKCAF CPMAFKTASS
TADHSTTQHP TQPHRPSQLI YKCSCEMVFN KKRHIQQHFY QNASTAQVGV FKCPECPLLF
LQKPELMQHV KSTHGVPRNV DELSSLQSSA DSSSSRPGPR VPAEPPALSV TARGSALPSS
RWGRGPEANR RAEARPRLRN TGWPCQECQE WVPDRESYVS HMKKSHGRTL KRYPCRQCEQ
SFHTPNSLRK HIRNNHDTVK KVYTCGYCTE DSPSFPRPSL LESHISLMHG IRNPDLSQTS
KARPSGGHSP QVNHLKRPVS GVGAAPDTSN GTPVSSTKRH KSLFQCAKCS FATDSGLEFQ
RHIPQHQKDS STAQCLLCGL CYTSAGSLSR HLFIVHKVRD QEEEEAEAAE PEEGSGEEVP
METRENGLEE SAEEPLVGDS ETGRSLGLAQ DEDGAQDAPS RPQTSQDRDS HTPSPHV
//
