ID W5PVL9_SHEEP Unreviewed; 736 AA.
AC W5PVL9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Adhesion G protein-coupled receptor L4 {ECO:0008006|Google:ProtNLM};
GN Name=ADGRL4 {ECO:0000313|Ensembl:ENSOARP00000014502.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014502.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014502.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014502.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014502.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AMGL01002704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01002710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PVL9; -.
DR Ensembl; ENSOART00000014715.1; ENSOARP00000014502.1; ENSOARG00000013529.1.
DR Proteomes; UP000002356; Chromosome 1.
DR Bgee; ENSOARG00000013529; Expressed in cardiac muscle tissue of left auricle and 52 other cell types or tissues.
DR ExpressionAtlas; W5PVL9; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15437; 7tmB2_ETL; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011:SF59; ADHESION G PROTEIN-COUPLED RECEPTOR L4; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..736
FT /note="Adhesion G protein-coupled receptor L4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869449"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..96
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 473..714
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 736 AA; 82313 MW; 44D86CB9E8422DDB CRC64;
MRLLPLLVGF STLLNCCCTQ NCTKTPCHPN AKCEIRNGAE GCYCNTGYSG NGVTICEDDN
ECGNLTQSCG ENANCTNTQG SYYCMCAPGF RSSSNEDKFI TNDGTTCIDI DEDSESFACG
DHAVCKKING GSNCSCREGY QTSTGSLFTL IDSIYCQKIV NPDCHLDNAC IAENINKTLT
KIRHIEEPVA LLREVYRNSL KDLSPMDIIT YTEVLAESSP LFINSTNSAK DTSSNSTLTE
FVKTLNNLVQ KDTFTVWDKL STNQRRTHLT KLIHTAEQAT LRISQNFQKT TQFDTNSSDI
ALKTFFFDSH HIKYIQPCMN MDGDNIKIFP KRKTAYDSNG SVAVAFLYYK SIGPLFSSSD
NLLEPQSYDK AEEEGRVISS VISLSISSNP PTLYELEKVT FTLSHIKTTD KYKSQCAFWN
YLPDTMNGSW SSEGCELTNS NDTHTSCRCN HLTHFAILMS SGSSIGIKDY NILTRITQLG
IIISLICLAL CIFTFWFFSE IQSTRTTIHK NLCCSLFLAE LVFLVGINTN SNKLFCSIVA
GLLHYFFLAA FAWMCIEGIH LYLIVVGVIY NKGFLHKNFY IFGYLSPAVV VGFSASLGYR
YYGTTKVCWL STENNFIWSF IGPACLIILV NLLAFGVIIY KVFRHTAGLK PEVSCYENIR
SCARGALALL FLLGTTWIFG VLHVVHASVV TAYLFTVSNA FQGMFIFLFL CILSRKIQEE
YYRLFKNVPC CFGCLR
//
