ID W5PVS5_SHEEP Unreviewed; 264 AA.
AC W5PVS5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Carbonic anhydrase {ECO:0000256|RuleBase:RU367011};
DE EC=4.2.1.1 {ECO:0000256|RuleBase:RU367011};
GN Name=CA13 {ECO:0000313|Ensembl:ENSOARP00000014558.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014558.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014558.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014558.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Reversible hydration of carbon dioxide.
CC {ECO:0000256|RuleBase:RU367011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:17544; EC=4.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000943,
CC ECO:0000256|RuleBase:RU367011};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU367011};
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718, ECO:0000256|RuleBase:RU367011}.
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DR EMBL; AMGL01113117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01113123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PVS5; -.
DR Ensembl; ENSOART00000014772.1; ENSOARP00000014558.1; ENSOARG00000013577.1.
DR Proteomes; UP000002356; Chromosome 9.
DR Bgee; ENSOARG00000013577; Expressed in metanephros cortex and 45 other cell types or tissues.
DR ExpressionAtlas; W5PVS5; baseline.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF81; CARBONIC ANHYDRASE 13; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS00162; ALPHA_CA_1; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU367011};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367011};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367011}.
FT DOMAIN 4..263
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 264 AA; 29857 MW; 112C35D0F9324B87 CRC64;
LHTITWSCKT KQNSPVHWNE FFPIADGDQQ SPIEIKTKEV RYDSSLRPLG IKYDASSAKI
ISNSGHSFNV DFDDTDDKSV LRGGPLTGSY RLRQFHLHWG SADDHGSEHM VDGVRYAAEL
HVVHWNSDKY PSFVEAAHEP DGLAVLGIFL QIGEHNPQLQ KITDILDSIK EKGKQIRFTN
FDPVCLLPPC RDYWTYPGSL TVPPLLESVT WIILKQPINI SSQQQLAAFR TLLCSREGET
AAFLLSNHRP PQPLKGRKVR ASFR
//
