ID W5PW93_SHEEP Unreviewed; 539 AA.
AC W5PW93;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000014726.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014726.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014726.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014726.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014726.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009381}.
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DR EMBL; AMGL01040073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01040074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01040075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01040076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PW93; -.
DR SMR; W5PW93; -.
DR STRING; 9940.ENSOARP00000014726; -.
DR PaxDb; 9940-ENSOARP00000014726; -.
DR Ensembl; ENSOART00000014944.1; ENSOARP00000014726.1; ENSOARG00000013730.1.
DR eggNOG; KOG2410; Eukaryota.
DR HOGENOM; CLU_014813_4_1_1; -.
DR OMA; EGPCVYA; -.
DR Proteomes; UP000002356; Chromosome 17.
DR Bgee; ENSOARG00000013730; Expressed in cerebellum and 50 other cell types or tissues.
DR GO; GO:0036374; F:glutathione hydrolase activity; IEA:InterPro.
DR GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR Gene3D; 1.10.246.130; -; 1.
DR Gene3D; 3.60.20.40; -; 1.
DR InterPro; IPR043138; GGT_lsub_C.
DR InterPro; IPR000101; GGT_peptidase.
DR InterPro; IPR043137; GGT_ssub.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR PANTHER; PTHR11686; GAMMA GLUTAMYL TRANSPEPTIDASE; 1.
DR PANTHER; PTHR11686:SF19; GLUTATHIONE HYDROLASE 5 PROENZYME; 1.
DR Pfam; PF01019; G_glu_transpept; 1.
DR PRINTS; PR01210; GGTRANSPTASE.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS00462; G_GLU_TRANSPEPTIDASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT ACT_SITE 357
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600101-1"
SQ SEQUENCE 539 AA; 57506 MW; C160DE568FBE0111 CRC64;
CGPQAFAHAA VAADSKTCSD IGRAILLQRG SPVDAAIAAL VCTGVVHPQS MGLGGGVIFT
IYNATTGKVE VINARETVPS SPIPALLDQC EQAQPLGIGA QWIGVPGELR GYAEAHRRHG
RLPWEQLFTP TIALLRGGFR VPNVLASFLH SPFLRPSLTE SSLRQLFFNG TEPLRSQDPL
PWPMLAATLE TVATEGAEAL YTGRLGQLLL EDIAKEGSRL TLQDLASFRP EVADALAMPL
GDYTLYSPPP PAGGAILSFV LNVLKGGCLT FSAGSTFPPG LEGRVNLYHH LVETLKFAGG
QRWRLWDPRS HPEVQNTSQD LLGEALAQHI RQQMDARGDH PLDHYSLAGA WTHRMGTAHV
SVLGEDGSAV AATSTINTPF GAMVYSPRTG ILLNNELLDL CWRHSQGSRA TPEPVPGERP
PSSMVPSILV SAARGAKLVI GGAGGELIIS AVAQAIMNKL WLGFDLQAAI KAPILHVDSK
GQVEFEPSFS QEVQKGLQDR GQEQSKRPFF LNVVQAVSQD GACVHAVADP RKGGEPSGY
//
