ID W5PWB8_SHEEP Unreviewed; 842 AA.
AC W5PWB8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Rho GTPase-activating protein 12 {ECO:0008006|Google:ProtNLM};
GN Name=ARHGAP12 {ECO:0000313|Ensembl:ENSOARP00000014751.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014751.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000014751.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014751.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000014751.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01024741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01024742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01024743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014955095.1; XM_015099609.1.
DR AlphaFoldDB; W5PWB8; -.
DR SMR; W5PWB8; -.
DR STRING; 9940.ENSOARP00000014751; -.
DR PaxDb; 9940-ENSOARP00000014751; -.
DR Ensembl; ENSOART00000014969.1; ENSOARP00000014751.1; ENSOARG00000013756.1.
DR GeneID; 101114797; -.
DR KEGG; oas:101114797; -.
DR CTD; 94134; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_015883_6_0_1; -.
DR OMA; PECHYAT; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000013756; Expressed in hippocampal formation and 54 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..74
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 266..299
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 365..392
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 470..571
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 652..840
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 153..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 95355 MW; FA6A180CEC81ED7B CRC64;
MKMADRGGKI LPGPVYIEVE YDYEYEAKDR KVVIKQGERY LLVKKTNADW WQVKPDESSK
AFYVPAQYVK EVGRRALMPP VKPATGLPNH SVKTAQSLHL QRSSENVNRL PELSSFGKTS
SSSVQGTGLV RDANQNFGPS YIPGQTVNLS LDLTHNNGKL NSDSHSPKVP GQNRTRLFGH
FPGPEFLEVE KAGFPQEQSC DSAGEGSERI QQDSESGDEL SSSSTEQIRA TTPPNQGRPD
SPVYANLQEL KISQSALPPV PGSPAIQING EWETHKDSSG RCYYYNRGTQ ERTWKPPRWT
RDTNASKGDS QSPGDQELLS SEENYYSICL SQSDSQCGSP PRGWSEELDE RGHTLYTSDY
TNEKWLKHVD DQGRQYYYSA DGSRSEWELP KYNASSQQQR EIIKSRSLDR RLQEPIVLSK
WRHSTIVLDA NDKESPSASK PCYPEHESSP SSPKHQDTGQ EKYGLLNVTK ITENGKKVRK
NWLSSWAVLQ GSSLLFTKTQ GSSTSWFGSN QSKPEFTVDL KGATIEMASK DKSSKKNVFE
LKTRQGTELL IQSDNDTVIN DWFKVLSSTI SNQTVEPDEA IEEEIPDSPG IEKHDKEKDQ
KEPKKLRSTK VSSIDSSEQK KTKKNLKKFL TRRPTLQAVR EKGYIKDQVF GANLSNLCQR
ENSTVPKFVK LCIEHVEQYG LDVDGIYRVS GNLAVIQKLR FAVNHDEKLD LKDSKWEDIH
VITGALKMFF RELPEPLFTF NHFNDFVNAI KQEPRQRVSA VKDLIKQLPK PNQDTMQILF
RHLKRVIENG EKNRMTYQSI AIVFGPTLLK PEKETGNIAV HTVYQNQIVE LILLEINSIF
GR
//
