ID W5PXC9_SHEEP Unreviewed; 128 AA.
AC W5PXC9; A0A6P3ESN7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=SH2 domain-containing protein 1A {ECO:0000256|ARBA:ARBA00013980, ECO:0000256|PIRNR:PIRNR037828};
GN Name=SH2D1A {ECO:0000313|Ensembl:ENSOARP00000015113.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015113.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015113.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015113.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015113.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytoplasmic adapter regulating receptors of the signaling
CC lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244,
CC LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with
CC SH2D1B/EAT-2. {ECO:0000256|PIRNR:PIRNR037828}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037828}.
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DR EMBL; AMGL01118135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004022415.1; XM_004022366.3.
DR AlphaFoldDB; W5PXC9; -.
DR SMR; W5PXC9; -.
DR STRING; 9940.ENSOARP00000015113; -.
DR PaxDb; 9940-ENSOARP00000015113; -.
DR Ensembl; ENSOART00000015333.1; ENSOARP00000015113.1; ENSOARG00000014085.1.
DR GeneID; 101117307; -.
DR KEGG; oas:101117307; -.
DR CTD; 4068; -.
DR eggNOG; KOG0565; Eukaryota.
DR HOGENOM; CLU_125532_1_0_1; -.
DR OMA; CVLCNGY; -.
DR OrthoDB; 3891423at2759; -.
DR Proteomes; UP000002356; Chromosome X.
DR Bgee; ENSOARG00000014085; Expressed in major salivary gland and 50 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0006968; P:cellular defense response; IEA:UniProtKB-UniRule.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd10400; SH2_SAP1a; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR017289; SH2_prot_1A.
DR InterPro; IPR035876; SH2D1A_SH2.
DR PANTHER; PTHR46051:SF1; IPPC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF037828; SH2_p1A; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130,
KW ECO:0000256|PIRNR:PIRNR037828}; Cytoplasm {ECO:0000256|PIRNR:PIRNR037828};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037828};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037828};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
SQ SEQUENCE 128 AA; 14181 MW; EE874C856AC861F0 CRC64;
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY IYTYRVSQTE
TGSWSAETAP GVHKRFFRKI KNLISAFQKP DQGIVIPLQY PVEKKPSARS TQGATGRRDD
PDVLLKAP
//
