ID W5PXM4_SHEEP Unreviewed; 479 AA.
AC W5PXM4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Zinc finger protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=ZNF2 {ECO:0000313|Ensembl:ENSOARP00000015208.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015208.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015208.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015208.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01078882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PXM4; -.
DR SMR; W5PXM4; -.
DR STRING; 9940.ENSOARP00000015208; -.
DR PaxDb; 9940-ENSOARP00000015208; -.
DR Ensembl; ENSOART00000015429.1; ENSOARP00000015208.1; ENSOARG00000014166.1.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_44_0_1; -.
DR OMA; TKPEIHG; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000014166; Expressed in longissimus thoracis muscle and 53 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14196; ODD-SKIPPED - RELATED; 1.
DR PANTHER; PTHR14196:SF11; ZINC FINGER PROTEIN 208-LIKE; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 67..138
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 227..254
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 255..282
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 283..310
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 311..338
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 339..366
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 367..394
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 395..422
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 423..450
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 451..478
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 54278 MW; 316B293F2D4C42AB CRC64;
MESPRPNYGW ERGRQNSLRR RTGFPTRRGS VFLGPEQSVP EDSALLCKES TLEGMAAVSP
TRCQDPVTFE DVAIVFTDEE WRSLVPTQRD LYKEVMLENY KSIVSLGLPI PGPDVIFQLK
RGDEPWLVEF HEFEGKEGAE NVSLDWETKP EIQGASEEGK SEGSLKEKLG RKGPPSPKFE
VYVLDGRLGT EKESPTVEAC KKPPSLEESL QHRAAPPKKF LTKERDQECS NCGKTFFDHS
SLIRHQRTHT GEKPYDCPEC GKAFSHRSSL SRHLMSHTGE SPYECSACGK AFFDRSSLTV
HQRIHTGEKP FKCSECGKAF FDRSSLTRHQ RIHTGESPYE CNQCGKAFSQ KSILTRHQLI
HTGRKPYECN ECGKAFYGVS SLNRHQKAHA GEPRYQCSEC GKAFFDRSSL TQHQKIHTGD
KPYECSECGK AFSQRCRLTR HQRVHTGEKP FECSVCGKVF SSKSSVIQHQ RRYAKQGID
//
