ID W5PXQ4_SHEEP Unreviewed; 1089 AA.
AC W5PXQ4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO4 {ECO:0000313|Ensembl:ENSOARP00000015238.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015238.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015238.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015238.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015238.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; AMGL01081889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01081898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PXQ4; -.
DR Ensembl; ENSOART00000015459.1; ENSOARP00000015238.1; ENSOARG00000014173.1.
DR HOGENOM; CLU_006685_1_3_1; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000014173; Expressed in hippocampal formation and 19 other cell types or tissues.
DR ExpressionAtlas; W5PXQ4; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF28; ANOCTAMIN-4; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 481..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 560..579
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 636..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 682..703
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 731..752
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 851..873
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 901..925
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 241..468
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 474..1054
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 136..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1053..1087
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1089 AA; 125774 MW; 190E3D2E5CA5A354 CRC64;
MASLTAYDKD ISSGSYNLSS ATTGSYYSCV SQVTIGYDAA GPVAIGLTHW KNPYAQGRPT
LPSDLPLFIS KDAGVPVYHQ SLTRKTELAT PLSCPASLSI TPVPSYSSSS QETLSQDTTG
LSLSIHGAEK RLQIHQRRSV ASRPGSRRLP VVRHSSLPPG RRSVKMETSS SGITNGRTKV
FHPVAKDVNI LFDELEAVNS PCKDDDSLLH PGNLTSTSDD ASRLEAGGET VPEKNKLNGL
YFRDGKCRID YILVYRKSNP QMEKREVFER NIRAEGLQME KESSLINSDI IFVKLHAPWE
VLGRYAEQMN VRMPFRRKIY YLPRRYKFMS RIDKQISRFR RWLPKKPMRL DKETLPDLEE
NDCYTAPFSQ QRIHHFIIHN KDTFFNNATR SRIVHHILQR IKYEEGKNKI VVGLNRLLTN
GSYEAAFPLH EGSYRSKNSI RTHGAVNHRH LLYECWASWG VWYKYQPLDL VRNRRYFGEK
IGLYFAWLGW YTGMLFPAAF IGLFVFLYGV ITLDHCQVSK EVCQATDIIM CPVCDKYCPF
MRLSDSCVYA KVTHLFDNGA TVFFAVFMAV WATVFLEFWK RRRAVIAYDW DLIDWEEEEE
EIRPQFEAKY SKKERMNPIS GKPEPYQAFA DKCSRLIVSA SGIFFMICVV IAAVFGIVIY
RVVTVSTFAA FKWALIRNNS QVATTGTAVC INFCIIMLLN VLYEKVALLL TNLEQPRTES
EWENSFTLKM FLFQFVNLNS STFYIAFFLG RFTGHPGAYL RLINRWRLEE CHPSGCLIDL
CMQMGIIMVL KQTWNNFMEL GYPLIQNWWT RRKVRQEHGP ERKISFPQWE KDYNLQPMNA
YGLFDEYLEM ILQFGFTTIF VAAFPLAPLL ALLNNIIEIR LDAYKFVTQW RRPLASRAKD
IGIWYGILEG IGILSVITNA FVIAITSDFI PRLVYAYKYG PCAGQGEAGQ KCMVGYVNAS
LSVFRISDFE NRSEPESDGS EFSGTPLKYC RYRDYRDPPH SLVPYGYTLQ FWHVLAARLA
FIIVFEHLVF CIKHLISYLI PDLPKDLRDR MRREKYLIQE MMYEAELERL QKERKERKKN
GKAHHNEWP
//
