ID W5PY25_SHEEP Unreviewed; 1081 AA.
AC W5PY25;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSOARP00000015359.1};
GN Name=BUB1 {ECO:0000313|Ensembl:ENSOARP00000015359.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015359.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015359.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015359.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015359.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01078906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004006233.1; XM_004006184.3.
DR AlphaFoldDB; W5PY25; -.
DR SMR; W5PY25; -.
DR STRING; 9940.ENSOARP00000015359; -.
DR PaxDb; 9940-ENSOARP00000015359; -.
DR Ensembl; ENSOART00000015584.1; ENSOARP00000015359.1; ENSOARG00000014305.1.
DR eggNOG; KOG1166; Eukaryota.
DR HOGENOM; CLU_296458_0_0_1; -.
DR OMA; NCEKGVG; -.
DR Proteomes; UP000002356; Chromosome 3.
DR Bgee; ENSOARG00000014305; Expressed in embryo and 51 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 6.10.130.20; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 11..182
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 782..1081
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 328..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 816
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1081 AA; 120740 MW; 1895EAA23EED7835 CRC64;
MDNPENVFQM FEAHMQSYKG DDPLGEWESY MRWVEENFPE NKEYLTTLLE HLMKEFLDKK
RYHNDPRFIN YCLQFAKCNS DLHQFFEFLH NHGIGTQAAP LYVAWAGHLE GQGEWQHAGA
VFRRGIQNQA EPTELLQQQY RMFQTRLTET HLSTQVRTSE PLHDAQILNQ MVTSNSNPGS
NSACISKNQG PQLPGATPAA GDKGSDMEQR VITISKSEYS SHASVADKAD VQQVVMYCKE
KLIRGESEFS FEELRAQRYN LRRKHEQWVN EERHYMKRKE ANALEEQLLK QKMDELHKKL
HQVVEMSQGN LPSSRGTSEV RPACLEAHTD SQQELRAPGL PAVPQQTSKN ADEKPGEAPS
VPLTASAVAT ALVSPAASQG VACPAPLAGP PVTDAMFSGG GRDARCVNKS THEFRPQSGA
EIKEGCETQK VVNTSSFHTT PNTSLGLVQA TPSKVQPSPT VHTKEALGFI MNVFQAPTLP
DISDDKEEWP SLGQNEFEAQ FQKNAPSSGA WGVNKIISSL SSAFPVFEDG NKENYGLPQP
KNKPAGARTF GERSVSRFPA KPNEVPHADE FLDDSTVWGV RCNKSLAPSP RSPGDFRSAA
QLASTPFHRL PADSAHPLED KENMVANQHT HVAVDPCARN KVEPLKERRF SPVEETSPDP
VCPTEGPSAS LLRLGQPAAA VLVSEAEQGL KACKVTDPDL ATAEDPAEAS AGLQAELMQA
GPPGTVNAPN FTVENPWDEE LILKLLSGLS KPVSSYPNTY EWACKLPAIK PKTEFQLGSL
LVYVDHFIGE GAFAQVYEVT HGDVNNSKNK EKFALKVQKP PNLWEFYIGT QLMERLNPGA
QHMFIRFYSA HLFQNGSVLV GDLYSYGTLL NAINLYKNTP EKVMPQALVL AFAIRMLCMI
QQVHDCEIIH GDIKPDNFIL GNRFLEQDNK DDDLSAGLVL IDLGQSIDMK LFPKGTAFTG
KCETSGFQCI EMLSNKPWNY QIDYFGVAAT IYCMLCGTYM KVKNEGGIWK PEGLFRRLPH
LDMWNEFFHV MLNIPDCHHL PSLDLLRQKL KKTFQEHYTS KIKTLCNRLI VLLLEYKRSR
K
//