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Database: UniProt
Entry: W5PY25_SHEEP
LinkDB: W5PY25_SHEEP
Original site: W5PY25_SHEEP 
ID   W5PY25_SHEEP            Unreviewed;      1081 AA.
AC   W5PY25;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSOARP00000015359.1};
GN   Name=BUB1 {ECO:0000313|Ensembl:ENSOARP00000015359.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015359.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000015359.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015359.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000015359.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   EMBL; AMGL01078906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004006233.1; XM_004006184.3.
DR   AlphaFoldDB; W5PY25; -.
DR   SMR; W5PY25; -.
DR   STRING; 9940.ENSOARP00000015359; -.
DR   PaxDb; 9940-ENSOARP00000015359; -.
DR   Ensembl; ENSOART00000015584.1; ENSOARP00000015359.1; ENSOARG00000014305.1.
DR   eggNOG; KOG1166; Eukaryota.
DR   HOGENOM; CLU_296458_0_0_1; -.
DR   OMA; NCEKGVG; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   Bgee; ENSOARG00000014305; Expressed in embryo and 51 other cell types or tissues.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 6.10.130.20; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF26; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          11..182
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   DOMAIN          782..1081
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          328..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         816
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1081 AA;  120740 MW;  1895EAA23EED7835 CRC64;
     MDNPENVFQM FEAHMQSYKG DDPLGEWESY MRWVEENFPE NKEYLTTLLE HLMKEFLDKK
     RYHNDPRFIN YCLQFAKCNS DLHQFFEFLH NHGIGTQAAP LYVAWAGHLE GQGEWQHAGA
     VFRRGIQNQA EPTELLQQQY RMFQTRLTET HLSTQVRTSE PLHDAQILNQ MVTSNSNPGS
     NSACISKNQG PQLPGATPAA GDKGSDMEQR VITISKSEYS SHASVADKAD VQQVVMYCKE
     KLIRGESEFS FEELRAQRYN LRRKHEQWVN EERHYMKRKE ANALEEQLLK QKMDELHKKL
     HQVVEMSQGN LPSSRGTSEV RPACLEAHTD SQQELRAPGL PAVPQQTSKN ADEKPGEAPS
     VPLTASAVAT ALVSPAASQG VACPAPLAGP PVTDAMFSGG GRDARCVNKS THEFRPQSGA
     EIKEGCETQK VVNTSSFHTT PNTSLGLVQA TPSKVQPSPT VHTKEALGFI MNVFQAPTLP
     DISDDKEEWP SLGQNEFEAQ FQKNAPSSGA WGVNKIISSL SSAFPVFEDG NKENYGLPQP
     KNKPAGARTF GERSVSRFPA KPNEVPHADE FLDDSTVWGV RCNKSLAPSP RSPGDFRSAA
     QLASTPFHRL PADSAHPLED KENMVANQHT HVAVDPCARN KVEPLKERRF SPVEETSPDP
     VCPTEGPSAS LLRLGQPAAA VLVSEAEQGL KACKVTDPDL ATAEDPAEAS AGLQAELMQA
     GPPGTVNAPN FTVENPWDEE LILKLLSGLS KPVSSYPNTY EWACKLPAIK PKTEFQLGSL
     LVYVDHFIGE GAFAQVYEVT HGDVNNSKNK EKFALKVQKP PNLWEFYIGT QLMERLNPGA
     QHMFIRFYSA HLFQNGSVLV GDLYSYGTLL NAINLYKNTP EKVMPQALVL AFAIRMLCMI
     QQVHDCEIIH GDIKPDNFIL GNRFLEQDNK DDDLSAGLVL IDLGQSIDMK LFPKGTAFTG
     KCETSGFQCI EMLSNKPWNY QIDYFGVAAT IYCMLCGTYM KVKNEGGIWK PEGLFRRLPH
     LDMWNEFFHV MLNIPDCHHL PSLDLLRQKL KKTFQEHYTS KIKTLCNRLI VLLLEYKRSR
     K
//
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