ID W5PY78_SHEEP Unreviewed; 1030 AA.
AC W5PY78;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN Name=ATP9A {ECO:0000313|Ensembl:ENSOARP00000015412.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015412.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015412.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015412.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015412.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
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DR EMBL; AMGL01026491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01026498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PY78; -.
DR SMR; W5PY78; -.
DR STRING; 9940.ENSOARP00000015412; -.
DR PaxDb; 9940-ENSOARP00000015412; -.
DR Ensembl; ENSOART00000015637.1; ENSOARP00000015412.1; ENSOARG00000014351.1.
DR eggNOG; KOG0210; Eukaryota.
DR HOGENOM; CLU_000846_3_1_1; -.
DR OMA; XVYFIAT; -.
DR Proteomes; UP000002356; Chromosome 13.
DR Bgee; ENSOARG00000014351; Expressed in cerebellum and 52 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR CDD; cd07541; P-type_ATPase_APLT_Neo1-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24092:SF49; PHOSPHOLIPID-TRANSPORTING ATPASE IIA-RELATED; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 48..70
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 82..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 281..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 311..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 829..849
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 855..877
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 907..927
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 933..954
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 961..981
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 987..1013
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 29..89
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 795..1022
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
SQ SEQUENCE 1030 AA; 116463 MW; 711881EC2AE6E3D4 CRC64;
DRPASRCSEW LRCCGGGEPR PRTVWLGHPE KRDQRYPRNV INNQKYNFFT FLPGVLFNQF
KYFFNLYFLL LACSQFVPEM RLGALYTYWV PLGFVLAVTI IREAVEEIRC YTRDKEVNAQ
VYSRLTARGT VKVKSSSIQV GDLIIVEKNQ RVPADMIFLR TSEKNGSCFL RTDQLDGETD
WKLRLPVACT QRLPTAADLL QIRSYVYAEE PNIDIHNFVG TFTREDSDPP ISESLSIENA
LWAGTVTASG TVVGVVLYTG RELRSVMNTA NPRSKIGLFD LEVNCLTKIL FGALVVVSLV
MVALQHFAGR WYLQILRFLL LFSNIIPISL RVNLDMGKIV YSWVIRRDSK IPGTVVRSST
IPEQLGRISY LLTDKTGTLT QNEMVFKRLH LGTVAYGLDS MDEVQSHIFS VYTQQPQVPP
AQKGSAPTTK VRRTMSSRVH EAVKAIALCH NVTPVYESNG VTDQAEAEKQ YEDSCRVYQA
SSPDEVALVQ WTESVGLTLV GRDQSSMQLR TPGDQILNFT ILQLFPFTYE SKRMGIIVRD
ESTGEITFYM KGADVVMAGI VQYNDWLEEE CGNMAREGLR VLVVAKKSLA EEQYQDFEAR
YVQAKLSVHD RSLKVATVIE SLEMEMELLC LTGVEDQLQA DVRPTLETLR NAGIKVWMLT
GDKLETATCT AKNAHLVTRN QDIHIFRLVT NRGEAHLELN AFRRKHDCAL VISGDSLEVC
LKYYEYEFME LACQCPAVVC CRCAPTQKAQ IVRLLQERTG RLTCAVGDGG NDVSMIQESD
CGVGVEGKEG KQASLAADFS ITQFRHLGRL LMVHGRNSYK RSAALSQFVI HRSLCISAMQ
AVFSSVFYFA SVPLYQGFLI IGYSTIYTMF PVFSLVLDKD VKSEVAMLYP ELYKDLLKGR
PLSYKTFLIW VLISIYQGST IMYGALLLFE SEFVHIVAIS FTSLILTELL MVALTIQSWH
WLMTVAELLS LACYIASLVF LHEFIDVYFI ATLSFLWKVS VITLVSCLPL YVLKYLRRRF
SPPSYSKLTS
//
