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Database: UniProt
Entry: W5PYC7_SHEEP
LinkDB: W5PYC7_SHEEP
Original site: W5PYC7_SHEEP 
ID   W5PYC7_SHEEP            Unreviewed;       423 AA.
AC   W5PYC7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-OCT-2019, entry version 41.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000015461};
GN   Name=KCNJ6 {ECO:0000313|Ensembl:ENSOARP00000015461};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015461, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000015461, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015461,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000015461}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMGL01012417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01012426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004003459.1; XM_004003410.3.
DR   STRING; 9940.ENSOARP00000015461; -.
DR   Ensembl; ENSOART00000015687; ENSOARP00000015461; ENSOARG00000014410.
DR   GeneTree; ENSGT00970000193368; -.
DR   OMA; NVGYNTG; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF19; PTHR11767:SF19; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01328; KIR32CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     93    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       57    196       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      203    372       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      390    423       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    392    423       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        182    182       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   423 AA;  48421 MW;  96DC3977A56527D3 CRC64;
     MAKLTESMTN VLEGDSMDQD VESPVAIHQP KLPKQARDDL PRHVSRDRTK RKIQRYVRKD
     GKCNVHHGNV RETYRYLTDI FTTLVDLKWR FNLLIFVMVY TVTWLFFGMI WWLIAYIRGD
     MDHIEDPSWT PCVTNLNGFV SAFLFSIETE TTIGYGYRVI TDKCPEGIIL LLIQSVLGSI
     VNAFMVGCMF VKISQPKKRA ETLVFSTHAV ISMRDGKLCL MFRVGDLRNS HIVEASIRAK
     LIKSKQTSEG EFIPLNQTDI NVGYYTGDDR LFLVSPLIIS HEINQQSPFW EISKAQLPKE
     ELEIVVILEG MVEATGMTCQ ARSSYITSEI LWGYRFTPVL TLEDGFYEVD YNSFHETYET
     STPSLSAKEL AELASRAELP LSWSVSSKLN QHAELETEEE EKNPEEQTER NGDVANLENE
     SKV
//
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