ID   W5PYN6_SHEEP            Unreviewed;      1150 AA.
AC   W5PYN6; A0A6P3EFE1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=PR domain zinc finger protein 10 {ECO:0000256|ARBA:ARBA00024120};
DE   AltName: Full=PR domain-containing protein 10 {ECO:0000256|ARBA:ARBA00029959};
GN   Name=PRDM10 {ECO:0000313|Ensembl:ENSOARP00000015571.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015571.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000015571.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015571.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000015571.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000256|ARBA:ARBA00003767}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AMGL01061484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01061485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004019599.1; XM_004019550.3.
DR   AlphaFoldDB; W5PYN6; -.
DR   SMR; W5PYN6; -.
DR   STRING; 9940.ENSOARP00000015571; -.
DR   PaxDb; 9940-ENSOARP00000015571; -.
DR   Ensembl; ENSOART00000015800.1; ENSOARP00000015571.1; ENSOARG00000014507.1.
DR   GeneID; 101119085; -.
DR   KEGG; oas:101119085; -.
DR   CTD; 56980; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_008174_0_0_1; -.
DR   OMA; IRVIFQN; -.
DR   OrthoDB; 5394783at2759; -.
DR   Proteomes; UP000002356; Chromosome 21.
DR   Bgee; ENSOARG00000014507; Expressed in major salivary gland and 56 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd19194; PR-SET_PRDM10; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 7.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR044403; PRDM10_PR/SET.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24403:SF48; PR DOMAIN ZINC FINGER PROTEIN 10; 1.
DR   PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF21549; PRDM2_PR; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   Pfam; PF12874; zf-met; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
SQ   SEQUENCE   1150 AA;  130018 MW;  7B652EC87DA00BC9 CRC64;
     MDSKDESSHV WPPAAEHEEN AAQVHFVPDA GTVAQIVYTD DQVRPPQQVV YTADGASYAS
     VDGPQHTLVY IHPVEAAQTL FTDPGQVAYV QQDATAQQAS LPVHNQVLPS IESVDGSDPL
     ATLQNPMARL EAKEEEDEDE DEDSEDEEEE DGEDTDLDDW EPDPPRPFDP HDLWCEECNN
     AHSSVCPKHG PLHPIPNRPV LTRARASLPL VLYIDRFLGG VFSKRRIPKR TQFGPVEGPL
     VRESELKDCY IHLKVSLDKG DRKDRDLHED LWFELSDETL CNWMMFVRPA QNHLEQNLVA
     YQYGHHVYYT TIKNVEPKQE LKVWYAASYA EFVNRKIHDI SEEERKVLRE QEKNWPCYEC
     NRRFISSEQL QQHLNSHDEK LDVFSRARGR GRGRGKRRFG PGRRPGRPPK FIRLEITSEN
     GEKCDDGTQD LLHFSTKEQF DEAEAATPNG LDQPEQPTLP LPQLPPEAPS SLEQEPDTHE
     LHLQPQHEES VLPAQSTLTA DDMRRAKRIR NAALQHLFIR KSFRPFKCLQ CGKAFREKDK
     LDQHLRFHGR EGNCPLTCDL CNKGFISSAS LESHMKLHSD QKTYSCIFCP ESFDRLDLLK
     DHVAIHINDG YFSCPTCKKR FPDFIQVKKH VRSFHSEKIY QCTECDKAFC RPDKLRLHML
     RHSDRKDFLC STCGKQFKRK DKLREHMQRM HNPEREAKKA DRSSRSKTFK PRITSTDYDS
     FTFKCRLCMM GFRRRGMLVN HLSKRHPDMK IEEVPELTLP IIKPNRDYFC QYCDKVYKSA
     SKRKAHILKN HPGAELPPSI RKLRPAGPGE PDPMLSTHTQ LTGTIATPPV CCPHCSKQYS
     SKTKMVQHIR KKHPEYAQLP NTIHTPLTTA VISATPAVLT TDSATGETVV TTDLLTQAMT
     ELSQTLTTDY RTPQGDYQRI QYIPVSQSTS GLQQPQHIQL QVVQVAPATS PHQSQQSTVD
     VAQLHDPQTY TQHAIQVQHI QVTEPPAPAM STSQVAGQPL SPSPQQSQQG LSPSHVAGSS
     SQGQALQQPP QGSTVQHTYL PNTWNSFRGY SSEIQMMTLP PGQFVITDSG VATPVTTGQV
     KAVTPGHYVL SESQSELEEK QASALSGGVQ VQPAAHSDLD PQTTSQQPTQ YIITTTTNGN
     GDSEVHITKP
//