ID W5PZ02_SHEEP Unreviewed; 791 AA.
AC W5PZ02;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN Name=PPP2R1B {ECO:0000313|Ensembl:ENSOARP00000015688.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015688.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015688.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015688.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015688.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AMGL01031220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01031221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5PZ02; -.
DR SMR; W5PZ02; -.
DR STRING; 9940.ENSOARP00000015688; -.
DR PaxDb; 9940-ENSOARP00000015688; -.
DR Ensembl; ENSOART00000015920.1; ENSOARP00000015688.1; ENSOARG00000014624.1.
DR eggNOG; KOG0211; Eukaryota.
DR HOGENOM; CLU_015533_2_0_1; -.
DR OMA; NRVEAMQ; -.
DR Proteomes; UP000002356; Chromosome 15.
DR Bgee; ENSOARG00000014624; Expressed in testis and 54 other cell types or tissues.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10648:SF9; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A BETA ISOFORM; 1.
DR Pfam; PF02985; HEAT; 5.
DR Pfam; PF13646; HEAT_2; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 12.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 116..154
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 193..231
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 270..308
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 309..347
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 337..568
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 348..386
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 387..425
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 430..468
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 469..507
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 508..546
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 586..624
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 625..663
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 664..699
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 701..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 791 AA; 86762 MW; CC3EC43D1E7B88A5 CRC64;
MNPCPYFFLL GKGHGGSFRL LSPSVFWSSD LQLRKRGPGG GPHLLCRHSV PGLPLPPSPG
LSPAYQGAGR GQGAGRGQGA LRAAVTRRRR KNMAGVAGPA TGSGAAGGDG DDSLYPIAVL
IDELRNEDVQ LRLNSIKKLS TIALALGVER TRTELLPFLT DTIYDEDEVL LALAEQLGNF
TGLVGGPDFA HCLLPPLESL ATVEETVVRD KAVESLRQIS QEHTPVALEA HFVPLVKRLA
SGDWFTSRTS ACGLFSVCYP RASIAVKGEI RQYFRSLCSD DTPMVRRAAA SKLGEFAKVL
ELDSVKSEIV PLFTNLASDE QDSVRLLAVE ACVSIAQLLS QDDIEALVMP TLRQAAEDKS
WRVRYMVADK FSELQKAVGP KITLNDLIPA FQNLLKDCEA EVRAAAAHKV KELCENLPME
GRETMIMNQI LPYIKELVSD TNQHVKSALA SVIMGLSTIL GKENTIEHLL PLFLAQLKDE
CPEVRLNIIS NLDCVNEVIG IRQLSQSLLP AIVELAEDAK WRVRLAIIEY MPLLAGQLGV
EFFDEKLNSL CMAWLVDHVY AIREAATNNL MKLVQKFGTE WAQNTIVPKV LVMANDPNYL
HRMTTLFCIN ALSEACGQEI TTKQMLPIVL KMAGDQVANV RFNVAKSLQK IGPILDTDAL
QEEVKPVLQK LGQDEDMDVK YFAQEAISAV AQRLRKLDFP VKDSEEPSAP GADKNHFLRP
RGPGEDTGKA QRDRVARVAS KEAAETAQFR GPGTAKGPAY QLHVNTRDTL PQLDTAEIVL
FLPKHRLISR I
//
