ID W5PZR8_SHEEP Unreviewed; 1118 AA.
AC W5PZR8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=MSH3 {ECO:0000313|Ensembl:ENSOARP00000015954.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000015954.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000015954.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000015954.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000015954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01094164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01094173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012034303.1; XM_012178913.2.
DR AlphaFoldDB; W5PZR8; -.
DR Ensembl; ENSOART00000016187.1; ENSOARP00000015954.1; ENSOARG00000014867.1.
DR GeneID; 101121679; -.
DR KEGG; oas:101121679; -.
DR CTD; 4437; -.
DR HOGENOM; CLU_002472_0_1_1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000014867; Expressed in gastric lymph node and 54 other cell types or tissues.
DR ExpressionAtlas; W5PZR8; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT DOMAIN 956..972
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..725
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 70..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 125841 MW; C05ACADCDA609333 CRC64;
MSRRKPASGG AAPANPASAK QAVLSRFFQS TGSLKSTASP AVAAEKADPD SDSAAPLASK
LPPQLQPHVA EIDRSKKRAL ESDRPVKKKA RKVQEKEGSD SVTSGNSEPK KHLRTRTVLK
SLEKLKEFCC DSALPQNRVQ TEPLQKKFAV LPKCTDFEDI DLLRAKNAVS SEDSKSQTSQ
KDKKFSHFGP SQRSYENLQK TSDSKPSNKR TKSIYTPLEL QYLEMKQQQK DAILCVECGY
KYRFFGEDAE IAARELNIYC HLDHNFMTAS IPTHRLFVHV RRLVAKGYKV GVVKQTETAA
LKAIGDNKSS LFSRKLTALY TKSTLIGEDV NPLVKLDDAV NVDEVMTDTS TSYLLCICEN
KENVKDKKKG NVSIGIVGVQ PATGEVVFDS FQDSASRSEL ETRILCLQPV ELLLPSDLSE
QTETLIHRVT AMSVRDDRIR VERMKNVYFE YSHAFQEVTE FYAKDVVDIK DSQSFSDIIN
LEKPVICSLA AIIRYLKEFN LEKVLSKPKN FKQLSGEMEF MTINGTTLRN LEILQNQTDM
KTKGSLFWVL DHTKTSFGRR KLKKWVTQPL LKLREINARL DAVSEVLHSE SSVFGQIENH
LRKLPDIERG LCSIYHKKCS TQEFFLIVKT LYHLKSEFQA LIPVVNSHVE SELLQTFILE
IPELLSPVEH YLKILNEQAA KTGDKTELFK DLSDFPLIKK RKDEIQDVTN KIQTHLQEIR
KILKNPSAQY VTVSGQEFMI EVKNSAVSCI PTDWVKVGST KAVSRFHSPF IVENYRHLNQ
LREQLVLDCS AEWLAFLENF SEHYHTLCKA VHHLATIDCI FSLAKVAKQG VYCRPTLQEE
RKILIKNGRH PVIDVLLGEQ DQFVPNSTDL SGDSERVMII TGPNMGGKSS YIKQVALITV
MAQVGSYVPA EEATIGIVDG IFTRMGAADN IYKGQSTFME ELTDTAEIIR KATPQSLVIL
DELGRGTSTH DGIAIAYATL EHFIRDVESL TLFVTHYPPV CELEKSYSQQ VGNYHMGFLV
NEDESKQDAG EEDQVPDSVI FLYQITRGIA ARSYGLNVAK LADVPGEILK KAASKSKELE
GLVNMKRKKL KSFAKLWTVN DAKDLQKWTE EEITDVSL
//
