ID   W5PZX0_SHEEP            Unreviewed;       444 AA.
AC   W5PZX0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN   Name=KRT24 {ECO:0000313|Ensembl:ENSOARP00000016006.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016006.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000016006.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016006.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000016006.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AMGL01018607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012041465.1; XM_012186075.1.
DR   AlphaFoldDB; W5PZX0; -.
DR   Ensembl; ENSOART00000016240.1; ENSOARP00000016006.1; ENSOARG00000014915.1.
DR   HOGENOM; CLU_012560_8_3_1; -.
DR   Proteomes; UP000002356; Chromosome 11.
DR   Bgee; ENSOARG00000014915; Expressed in epididymis and 42 other cell types or tissues.
DR   ExpressionAtlas; W5PZX0; baseline.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR002957; Keratin_I.
DR   PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR   PANTHER; PTHR23239:SF207; KERATIN, TYPE I CYTOSKELETAL 24; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   SUPFAM; SSF46579; Prefoldin; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356}.
FT   DOMAIN          54..370
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          58..92
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          169..295
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        375..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  48546 MW;  3A10A0170E899FD8 CRC64;
     MSCSSRMPSS RAGGSSSVRV SAGGSSFSSG SRIGLGGGSA RSFRGGAGSY GLSEKQAMQN
     LNDRLANYLD KVRALEEANV DLENKIKQWY EKFGPGSRDG GAGRDYSKYY PVIDDLKNQI
     ITATTENAGI ILQIDNARLA ADDFRLKYEN ELHLRQTVEA DINGLRKVLD DLTMTRSDLE
     MQIESLTEEL AYLKKNHEEE MKTMQGSSGG DVTVEMNAAP GTDLTKLLND MRAQYEELAE
     QNRREAEEQF NKQSASLQAQ ISTDAGAASS AKNEITELKR TLQALEIELQ SQLAMKSSLE
     GTLADTEANY VVQLSQIQMQ ISSLEEQVCQ IRGETECQNA EYEQLLDIKT RLEMEIETYR
     RLLDGEGGGS GFGGSDYRSS GSRNMGSRNM GSRDSSVSDG SRSGTCVQGR DPSKSRVTKT
     IVEEVVDGKV ISSQVSNVSE VKLK
//