ID W5Q0H6_SHEEP Unreviewed; 777 AA.
AC W5Q0H6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Semaphorin-3D {ECO:0008006|Google:ProtNLM};
GN Name=SEMA3D {ECO:0000313|Ensembl:ENSOARP00000016212.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000016212.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000016212.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000016212.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000016212.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMGL01086644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01086645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01086646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01086647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5Q0H6; -.
DR SMR; W5Q0H6; -.
DR STRING; 9940.ENSOARP00000016212; -.
DR PaxDb; 9940-ENSOARP00000016212; -.
DR Ensembl; ENSOART00000016446.1; ENSOARP00000016212.1; ENSOARG00000015109.1.
DR eggNOG; KOG3611; Eukaryota.
DR HOGENOM; CLU_009051_5_0_1; -.
DR OMA; KIYWPAT; -.
DR Proteomes; UP000002356; Chromosome 4.
DR Bgee; ENSOARG00000015109; Expressed in testis and 49 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR CDD; cd05871; Ig_Sema3; 1.
DR CDD; cd11252; Sema_3D; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041416; IL-1RAcP-like_ig.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042582; Sema3D_Sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF36; SEMAPHORIN-3D; 1.
DR Pfam; PF18452; Ig_6; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..532
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 565..682
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 738..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..764
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 89686 MW; 80CD73612AECA8D1 CRC64;
MVVTKDERPK SRSHNFHLFH ALMMISMTML FLPVIRTSKQ NIPRLKLTYK DLLLSNSCIP
FLGSSEGLDF QTIMLDEERG RLLLGAKDHI FLLSLVDLNK NFKKIYWPAA KERVELCKLA
GKDANTECAN FIRVLQPYNK THVYVCGTGA FHPICGYIDL GIYKEEVIFK LDTHNLESGR
LKCPFDPQQP FASVMTDEYL YSGTASDFLG KDTAFTRSLG PTHDHYIRTD ISEHYWLNGA
KFIGTFPIPD TYNPDDDKIY FFFRESSQEG STSDKTIISR VGRVCKNDVG GQRSLINKWT
TFLKARLICS IPGSDGADTH FDELLIEDIY LLPTRDERNP VVYGVFTTTS SIFKGSAVCM
YSMADIRAVF NGPYAHKESA DHCWVQYDGR IPYPRPGTCP SKTYDPLVKS TRDFPDDVIS
FIKRHPVMYK SVYPVLGRPS FKQINVDYRL TQIVVDHVVA EDGQYDVMFL GTDIGTVLKV
VSISKEKWNI EEVVLEELQI FKHSSIILNM ELSLKQQQLY VGSRDGLVQL SLHRCNTYGK
ACADCCLARD PYCAWDGHAC SQYVPTSKRR ARRQDVKYGD PITQCWDIED SISEAADEKV
IFGIEFNSTF LECIPKSQQA SIKWYIQRSG DEHREEVKPD ERIIKTEYGL LIRSLQKKDS
GLYYCKAQEH TFTHTVVKLT LNIIENEQME NTQRAEHEEG PVKDLLAESR LRYKDYIQIL
SSPNFSLDQY CEQMWHREKR RQRNKGSPKW KHMQEMKKKR NRRHHRDLEE IPRAMAT
//
